ODM-208 (MK-5684): phase 3 trial started

[Maxone73]

Data from phase 2 study are encouraging:

urologytimes.com/view/oral-...

These are the two phase 3 studies, OMAHA 1 and 2...Omaha!! Omaha!! Omaha!!! (sorry, having a Peyton Manning moment...)

appliedclinicaltrialsonline...

[CAMPSOUPS]

ODM-208 makes news again. Thanks it satisfies my curiosity as to how this has gone. Now into phase 3 trials.

As I said I was in the phase 2 trial and despite eventually progressing I feel this is going to be a 3rd generation ADT in the future. Well what do I know. Its anecdotal but anyway I think it will have promise/benefit for future patients.

[Maxone73 in reply to CAMPSOUPS]

Hopefully soon!

[SC19]

Thank you for sharing this. My dad starts on this trial tomorrow. My concern is that I don’t think my dad has the AR LBD mutation that all the studies are saying responds the best to the drug. He’s also just been told he has a couple of new mets on his lungs (has always been bone previously). Why would they put him on this treatment if he doesn’t have the mutation? Thanks, from a stressed out daughter.

[Maxone73 in reply to SC19]

Hi there! As you said, I think because those with the mutation respond better, but it does not mean that those without have no response. are there other trials he could join?

[SC19 in reply to Maxone73]

This is the only one he has been offered so far. Can you go from one trial to another? Naively I thought having no mutations would be a good thing but it seems to limit what they can target?

[Maxone73 in reply to SC19]

yes some drugs perform better on mutated cells, for example olaparib on BRCA mutations. I do not know what is available in the UK at the moment as clinical trials but I think he could be accepted in some other trial as well, I am not sure about how long it would take tho, maybe he can start with this and see if it works?

[SC19 in reply to Maxone73]

Yes I suppose so. My concern is that I don’t want him to be part of a non-mutation group just to prove that it doesn’t work on them, if that makes sense ?

[Maxone73 in reply to SC19]

I understand, check if you can search for trials in the uk like cancerresearchuk.org/about-... or bepartofresearch.nihr.ac.uk/