PTEN and TMPRSS2

[StayingOptimistic]

I have a few questions please and appreciate some feedback:

1) Does having PTEN and TMPRSS2 mutations speed up the time to castrate resistant?

2) Any treatments out there targeting these mutations?

3) Any thing I can take to fix some of this? Supplements or anything?

Thanks and happy holidays

[Tall_Allen]

1) Yes

2) ipatasertib

thelancet.com/journals/lanc...

3) No

[StayingOptimistic in reply to Tall_Allen]

Thanks, TA. but I think the link you gave me discusses patients who are castrate resistant. Does it make any difference since I am still hormone sensitive?

[Tall_Allen in reply to StayingOptimistic]

See #1

[treedown in reply to Tall_Allen]

Am I correct in these patients showed PTEN loss in new tumors (metastes) as opposed to the original tumor. Or was it the orinal and/or new tumors? Or would it even matter?

[Tall_Allen in reply to treedown]

It was determined from metastases.

[treedown]

I have PTEN loss and not aware of any actionable options. I am just waiting for CR so time will tell.

[KocoPr]

Don’t take NO for number 3! Even though you’re hormone sensitive. Best to address it now before CRPC if you can.

You must research and do more research. PTEN is common enough that plenty of work is being done on it.

pubmed.ncbi.nlm.nih.gov/373...

Deregulated microRNAs Involved in Prostate Cancer Aggressiveness and Treatment Resistance Mechanisms

pubmed.ncbi.nlm.nih.gov/331...

The PTEN Conundrum: How to Target PTEN-Deficient Prostate Cancer

Also always go to the bottom of these “pubmed” sites and check out “similar articles “ and especially sited by” as they are newer articles.