PTEN gene & hormone resistant

[StayingOptimistic]

I would really appreciate your response on : how long it took you to become castrate resistant while having a PTEN gene mutation?

[StayingOptimistic]

Thanks for responding. I don’t even know what is the gene is all about and how it will impact my cancer prognosis. Just read that people who has it, usually have bad prognosis.

[dhccpa in reply to StayingOptimistic]

You asked a very good question.

[tango65]

The PTEN gene loss facilitate cell division. The cancer may have a short PSADT. The time the cancer takes to become castration resistant depends on multiple factors, PTEN loss, other mutations such as P53, RB1, etc. and in the treatments used to control the cancer.

Pten loss is a common mutation in many cancers but it doesn't make it a good thing to have a cancer with this mutation.

[HikerWife]

Hi, Ank1 - my husband has the PTEN mutation as well, so your post caught my eye. Unfortunately I don't know the answer to your question (my husband is still HS 14 months into the journey. Fingers crossed.) Anyway, it's always a good idea to check the profile page of responders, and see how long they've been on board here on the forum. Tall_Allen is our resident expert on all things PCa, and there are many, many longtime members of the forum with a lot of knowledge. All the best to you.

[Milo786 in reply to HikerWife]

Hi. What treatments has your husband had so far.

[HikerWife in reply to Milo786]

Triplet therapy: Lupron, abiraterone, and docetaxel chemo.

[Maxone73]

I am keeping an eye on a molecule called SBFI-103 , that serves exactly to resensitize PTEN mutated PCa to hormonal therapy

[treedown]

I am not sure what my mets have but my original tumor had PTEN. Nothing was actionable in 2019 and not sure anything is now but the upside is nothing is left of that tumor. I would need a biopsy on one of my mets to see what it has. And there's no point of doing that until I am CRPC, unless I want to pay for it out of pocket. That may be tomorrow (next blood draw) or years from now. I'll worry about it then. I know where your question is coming from and I hope you're able to wrap your head around it to get you to a place of relative peace.

[APK3]

Reading your bio you seem to have been at this battle a number of years. I apploud your strength and resiliency.I have just started my journey and would be super pleased to have a survival time like yours. Have you asked your oncologist? Might be the person that would have an answer that could settle your mind.I have Pten loss, not mutation but it's probably not helpful. I think Magnus answered this question with a study out of Jordan which showed minimal time between pten loss and intact as far as reaching castrate resistance. A couple of years with just a couple of months between becoming resistant but everyone is different I'm finding out...Not sure this post is helpful but I do feel your stress as I myself feel the same and was not pleased to have found about my mutation and it creeps back into my mind from time to time. Hopefully you can find the answers you seek.