I will keep you posted, also because it's a very fascinating technique that could potentially solve many health problems (and of course be used for evil...but that's not CRISPR fault, it's a fault in our brain!...which obviously CRISPR cannot fix!)
"In addition, we also analyzed whether “i-CRISPR” has practical feasibility in patients. As we previously reported, the mutation burden was 1.0 per megabase (Mb), and the median substitution rate was 1.4 per Mb in our cohort of 208 prostate cancer patients [15]. There were more than 100 mutation sites suitable to be targets of our strategy in each prostate cancer patient through rough estimation. Analysis of the data of 2554 European prostate cancer patients [15] also suggested that on average, there are more than 100 DNA mutation sites suitable for CRISPR-specific cleavage in each patient.
These results also suggest that our strategy has great advantages in solving the cancer evolution problem faced by current cancer therapy treatments. Moreover, with the future development of sequencing and bioinformatics technologies such as clonal evolutionary analysis, it will be possible to identify the original mutations which is universal in all the cancer cells from one patient. Using our strategy to specifically targeting these original mutations may also overcome the problems caused by cancer heterogeneity."
Rice University professor waits on FDA to approve what she hopes will be a cure for prostate cancer
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