Yes! I’ll be darned! First CRISPR approval, in the UK

[Maxone73]

this is not about prostate cancer but about a paradigm shift:

ft.com/content/ab87cac0-4b1...

[Soumen79]

So in ancient indian philosophy we used to believe its your wish that shapes your future. Do we see one here? Since you join us, you are wishing wishing and wishing, and here we go, thank you Maxone73!

[Maxone73 in reply to Soumen79]

Namaste! I truly believe I can try that. Been diagnosed metastatic directly this past August...dammit I am tired of this disease already!

[skiingfiend in reply to Maxone73]

I was diagnosed last Oct and for the first 3-4 months I spent a lot of my time imersering myself in the literature just to try to wrap my head around this new situation I found myself in.

After that I needed to take a cancer vacation and just live my life. Now I try to limit myself to 1 hour per day, sometimes I'm active here for a week or 2 and then I drop out for a while.

Take care of yourself and your family today, have some fun, don't obsess over the cancer, it'll still be here when you want to come back to it.

ciao

[Maxone73 in reply to skiingfiend]

I have bad days and good days. I am lucky because physically I am fine even after 3 doses of docetaxel, I work out even more than I did before the diagnoses (and that says a lot since I have always worked out since age 17). Therapies seem to be working at the moment...the uncertainty of the possible future treatments is killing me. But yes, I need to take is as a marathon, it's not a sprint for sure.

[Tjc1 in reply to skiingfiend]

I second that. I read and read and read. Then I put it down for a year or so. Come back look around. I'm having some problems lately and a PSMA Scan is in order. I'm visiting now to see what's new on the treatment front as the Xtandi is not doing its job anymore. I can't complain I think I got 4 years out of it, and this week is 13 years since diagnosis.

[skiingfiend]

Yeah, the docetaxel has got you lashed to the mast of always on thinking about cancer because of the 3 week cycles. Hopefully, when you finish you'll get a nice long run (years) on adt + darolutamide. What is your ADT cycle: 1 or 3 months?

I was on monthly firmagon, but switched to 4 month eligard, my MO consult cycle is also 4 month. So now I only spend about 2 hours - 3 times a year interacting with the Cancer system, well at least for now until something changes for the worse.

[Maxone73 in reply to skiingfiend]

Monthly, but I don't need to go to the hospital for that, one of my nieces is a nurse and she injects it. But I still need to go for the "precautional" denosumab every 8 weeks.

[Soumen79]

Sailing through docetaxel will clean your body, upto 6 cycles you will feel not much, then good food habits will kick in, more intense drive for exercise will make your body stronger, meditation and lack of testosterone will make you a calm easy going person - for me I have been my better version of myself after this dx, not bad right, Maxone73? You will see and enjoy all these for sure, but that uncertainty of possible future treatment is a real thorn, I fully understand your efforts, I have been doing that for last 2 yrs, being an IT developer (data engineer to be precise, your data for AI is prepared by us) I am used to see quick result all my life, now this slowness of productionisation of medicine, driving me nuts, thank you for all your effort, let me know I can be of any help to this quest, our quest.

[Maxone73 in reply to Soumen79]

You are so right! Always been active, in sports as in music apart from my job. My body is weaker, I have been forced to decrease the weights I used because of bone metastatis ("you never know" they told me), but at the same time it is stronger as is my will to workout daily. Good habits are helping me a lot. But my mind is completely fucked up, not as sharp as I was. And I cannot play any music it seems. Got myself some new gear but still, music requires a constant effort to learn new parts and perfect your playing and sometimes I am just like "Is it worth the effort?". I am slowly but steadily getting to the point where "Yes it is worth it, everything is worth your time apart from feeling sad!". I have found also some peace of mind by joining a calculus class online, math requires my full attention (as does weightlifting) and I feel better after a good session. I must learn to live with this frustration of feeling so close and yet so far from a solution. I am looking into osteo-immuno-oncology lately, because the METS are the real enemy here (I am just waiting for J_O_H_N to read what I have just written 😆😆 ), but I realize it is still not a "real" branch of oncology. I hope in new AI models that can start to work on fixing mets.

[Soumen79 in reply to Maxone73]

I underwent exactly same fidgety time in 2021, disease means dis ease, first 6 months after dx, then it started to ease out, give youself time, dont rush into things, take a deep breath and utter your prayer, but dont push it, it will happen (do i fully believe in this myself? May not yet, but i see few things working out, still i cant fully believe, alas) time is a true healer, 2 years down the line you will get to know that.

[Maxone73 in reply to Soumen79]

thank you brother

[Soumen79 in reply to Maxone73]

youtu.be/-RVVq0uDAEE?si=6oo...(Not working as expected?)

In the above video, Eugene Kewon , the premier prostate cancer specialist, told a funny thing, he said expense of r & d becoming prohibitive, due to, surprisingly, data analysis cost, your ai ml and my data transformation - data people is charging huge, is there anything we can think out of this, some collaboration?

[Maxone73 in reply to Soumen79]

Yes, but competition is going to lower the cost, together with quantum computing. It's truly a huge amount of data that they have to crunch. From my side I would take part in any project related to cancer as volunteer, of course I have a lot to learn because it's not my field!

[Maxone73 in reply to Soumen79]

I am looking into volunteering for some project as IT developer. I need to start somewhere!

[Soumen79 in reply to Maxone73]

Dr Eugene or his team replies by mail, should I try, message me if you think so and will discuss our capabilities and propositions

[Maxone73 in reply to Soumen79]

Why not? Even simple things like data preparation, duplicates removal and stuff like that...I have some rust to remove and some AI libraries to explore.

[Soumen79 in reply to Maxone73]

Let me try..will let you know.

[Tjc1 in reply to Maxone73]

Wow, you have trouble with music too? I thought it was just me. I played at 17 a little while, some at about 22 then got married and had kids. Picked the guitar up again a couple years ago. Not having the muscle memory built in so to speak, I can tell I have problems remembering chords words, luckily I found a group of wonderful people I play with once a week . That are so good at accepting newbies, and the challenged.It's bad when you have trouble remembering words to your own songs 🤣🤣

[Maxone73 in reply to Tjc1]

Well, let's say it's more a mood thing rather than muscle memory or memory in general. I have been playing for 40 years and I don't like to see it fading away from me. But last week I played! I picked up the classical guitar and I played Lagrima, an old piece from Tarrega...and then I picked up the electric guitar, turned on the new amp (2nd time that I turned it on) and started playing and learning Midnight by Joe Satriani....had fun, till midnight...thank god neighbour is quite deaf

[Tjc1 in reply to Maxone73]

Yes the mood is a big factor. I had a big break from lupron. 18 months or so. Feeling great. PSA doubling in six months so back on. .

[j-o-h-n]

I can't log into the site.......... They want my cookies.........and Damn if I'm gonna share my cookies with a bunch of people I don't know............. (Unless they're young females and beautiful....... then we can exchange them)........

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 11/17/2023 7:54 PM EST

[Lemonpower]

Can't get through the paywall. Is it possible to post top couple of graphs.

[Maxone73 in reply to Lemonpower]

biopharmadive.com/news/cris...

[Maxone73]

damn paywalls, they let you read an article and then they stop you from reading it again

[Maxone73]

here you go!

biopharmadive.com/news/cris...