PSA increase.

[Letsfish]

My PSA has increased from .13 to .73 in 3 1/2 months. Does this mean I am castrate resistant. Or does it need to increase over a couple more samples first. Can my PSA change this much for other reasons. I am currently on Lupron. Thanks for any input.

[Tall_Allen]

It's gradual. No need to change therapies until PSA ≥2 or rapidly doubling.

[Letsfish in reply to Tall_Allen]

Thank you. Much appreciated

[MoonRocket]

I'd add a Abiraterone or enzalutimide now. Why let it get to 2 when you know you're starting another treatment anyway? It would be different if you were .17 and then .27...but you increased to .7 in 3 months. You can get another PSA to confirm..but I doubt your PSA is increasing linearly.

[dac500]

Your PSA increased over 5 times in 3 and 1/2 months. That is it is rapidly increasing. Since you are on Lupron, your testosterone level should be at castrate level. My situation was very similar to yours my PSA jumped from 0.3 to 0.8 in 3 months. Luckily I had a PSMA PET/CT scan which found new lymph nodes PSMA avid. Oncologist have added Zytiga + Prednisone to Lupron.

[Letsfish]

thanks, I’ll put a call into my MO

[Buddy1950]

Almost exactly what I am at ... Mayo added Abiraterone... now 6 week psa test is .1 Going back for scans next month. On Firmagon and Abiraterone. Was undetectible for 5 years, but recently up to .7 in 3 months.

[Teacherdude72]

Actually other than Tall Allen the one to ask is your Medical Oncologist

[gsun]

Why was abi not started right away with lupron?

[dhccpa]

Did you have your prostate removed or radiated? That .13 is pretty low for just Lupron with prostate. My all-time low was .5.

[Letsfish]

MO said we will wait and see what my PSA looks like in 3 months. I don’t know why abi was not started with Lupron, should have it been. Yes I still have my prostate and no radiation as of yet.