PSMA Scan Results

[Amberliteyears]

I have attached results of my husband’s PSMA scan. I’m unable to determine if he is expressing PSMA by this report. The scan was done to determine eligibility for Pluvicto. Any insight is greatly appreciated. We see his oncologist Monday.

[Tall_Allen]

Yes, plenty of target sites for Pluvicto.

[Amberliteyears in reply to Tall_Allen]

Thanks for clarifying TA. Would you mind providing your interpretation of the scan results? I will try to provide a bio soon, just so overwhelmed with worry and my own Parkinson’s diagnosis has slowed me down a bit. He was diagnosed in 2006 at 52 (now 69) and had a RP, Gleason 3 +4 =7, PSA 7, with a BCR in 2015. SBRT given with the thought it was confined to prostate bed because of negative CT and bone scan, 40 treatments if I recall. Did not work as PSA continued to rise. Casodex, lupron, Erleada, zytiga, Xtandi, Nubeqa, failed docetaxel after 3 treatments, 10 cabizataxel treatments with good results for 8 months or so, cabizataxel re-challenge 10 treatments with so-so results. Currently on lupron, xgeva and Nubeqa which has failed based on Monday’s PSA of 85. Metastatic in 2021. He has not had any chemo for 2 months and PSA rose drastically. Do you think docetaxel re-challenge is worth pursuing? Provenge? He had genetic testing which indicated he was not a candidate for lynparza. Hope this all makes sense, tired and feeling afraid. Thanks so much for all you do.

[Tall_Allen in reply to Amberliteyears]

I think hiis Oncologist will take you through it on Monday. I just wanted to allay any fears you might have that he would not qualify for Pluvicto. I think he will, based on that, and it is a good next step. You may want to discuss getting an FDG PET scan too.

[Amberliteyears in reply to Tall_Allen]

Thanks TA, much appreciated.

[Vynbal in reply to Tall_Allen]

What additional information would you hope to get from the FDG PET scan in this case?

[Tall_Allen in reply to Vynbal]

prostatecancer.news/2019/12...

[Bowmaster in reply to Amberliteyears]

Hi. I am in the same boat and this week i am going for PET SCAN . I was operated 2002 and five years later the PSA came back and it is at 85 now . Had bone and CT scans done every year and nothing .I HAVE NEVER TAKEN ANY DRUGS OR TREATMENTS SO FAR . The problem is the doctors don't know what treatment i should have . I hope now the pet scan will show that there is no mets anywhere in my body . I am praying 24/7 ! I was 47 years old when they removed my prodtate and in two months I will be 69 God willing .

[Amberliteyears in reply to Bowmaster]

That’s amazing you’ve had no treatment. Sending best wishes for a great outcome.

[Cactus297 in reply to Bowmaster]

So happy for you😇 that your PC journey has gone so well!🙏🏻

[Peace-to-you]

Just a suggestion…have a radiation oncologist look at the report in addition to your MO. Pluvicto is a radiopharmaceutical and better understood by an RO.

[Amberliteyears in reply to Peace-to-you]

Thank-you, I’ll do that.

[Gumbo2023]

Do your research on Pluvicto. After 4 treatments I am showing improvements on pmsa scan.

[Amberliteyears in reply to Gumbo2023]

That’s excellent to hear! I’ve researched Pluvicto extensively and will continue to do so. Appreciate your input.

[Cactus297 in reply to Gumbo2023]

That’s great news!

[j-o-h-n]

For us Lay People

Gleaned from Dr. Google, Schmoogle:

PLUVICTO is a radiopharmaceutical used to treat adults with an advanced cancer called prostate-specific membrane antigen–positive metastatic castration-resistant prostate cancer (PSMA-positive mCRPC) that: • Has spread to other parts of the body (metastatic), and • Has already been treated with other anti-cancer treatments.

PLUVICTO is a ready-to-use solution for single use only. To ensure there is no product mixing, the intravenous (IV) catheter should only be used to administer PLUVICTO during the infusion.2

How PLUVICTO is supplied: Colorless type I glass, 30-mL single-dose vial. The product vial is in a lead-shielded container Volume: Solution volume is adjusted from 7.5 mL to 12.5 mL to provide a total of 7.4 GBq (200 mCi) of radioactivity at the date and time of administration

PLUVICTO dosing schedule2

Administered every 6 weeks for up to 6 treatments

PLUVICTO solution for injection contains 7.4 GBq (200 mCi) (at time of use)

Administered once every 6 weeks for up to 6 treatments, or until disease progression, or unacceptable toxicity

Slow intravenous (IV) injection (1 to 10 minutes) or infusion.

Is PLUVICTO effective?

Compared with patients who received standard of care alone, patients who received Pluvicto demonstrated a significantly better imaging-based progression-free survival (8.7 months versus 3.4 months) and overall survival (15.3 months versus 11.3 months.

Based on the above, I hope I didn't do a disservice to any of our members and that I should only stick to humor and silliness......

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 09/30/2023 1:33 PM DST

[Boywonder56 in reply to j-o-h-n]

I pass no judgement....but laughter is the best medicine....and you have made my journey a whole lot better by your humor than your attempts at being a PDR ....No kin to FDR....

[j-o-h-n in reply to Boywonder56]

OOOOOOOOOO shoot, I guess I came off like a Puzzy... Sorry....(slaps self silly..... ah that's much better)...Thanks for the heads up -- (woman's gratitude to da dude).....

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 10/01/2023 10:54 PM DST

[j-o-h-n in reply to Boywonder56]

PDR = Physicians' Desk Reference. FDR = Fraudulent Document Recognition.

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 10/02/2023 11:09 AM DST

[Boywonder56]

I pass no judgement.

[j-o-h-n in reply to Boywonder56]

youtube.com/watch?v=co6f-1z...(Not working as expected?)

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 10/01/2023 11:08 PM DST

[Nfler]

John said it best Pluvicto is the way to go. also maybe look into bat therapy, as the latest 5 yr study is showing low testosterone is causing adv prostate cancers and test saturation is showing to stabilize and or reduce tumor n cancer cells… hang in there n good luck 🍀

[Amberliteyears in reply to Nfler]

Thank-you so much, I have been reading about BAT therapy and will explore further.