Pylarify PSMA PET Scan

[jcarey79]

I have seen several posts that specifically mention "Pylarify" PSMA PET scan. Is the Pylarify agent a specific brand name for the F18 agent used in a PSMA PET Scan or is this a different type of PSMA PET Scan? Is there any difference in the sensitivity of the Scan?

I am asking because I am scheduled for a PSMA PET Scan on Monday.

Thanks,

John

[Tall_Allen]

There are several PSMA radioindicators. Why are you getting it? Rising PSA?

[jcarey79 in reply to Tall_Allen]

I have been on holiday from my ADT regimen (Orgvyx and Xtandi) for a year. PSA was undetectable. (Actually, Testosterone level was almost undetectable at 16). PSA has been rising- 0.16 in Feb, 0.32 in May to 0.65 in July. Testosterone level is now at 308 in July.

So, the rising PSA, the doubling time, and the lack of any treatment is the reason for the PSMA PET Scan.

Is one isotope better than another?

[Tall_Allen in reply to jcarey79]

Pylarify is one of the best:

prostatecancer.news/2016/12...

[Jpburns]

Mine was piflufolastat F-18, which I guess is under the brand name Pylarify, but I really hadn’t known until I looked it up today. It’s not like I got to pick and choose.

[NanoMRI]

Your bio indicates you had a clear PSMA this past May. Was that done with a different contrast agent?

As to differences in sensitivity, the two public doc's I follow, Raymond with UCLA and Kwon with Mayo, both speak to hard to know which if any of the available imaging methods will be 'successful' at lower PSA levels, and to consider having concurrent MRI and perhaps a second different contrast agent for comparison.

My current Pylarify, done at 0.033, (yes 0.033) identified a 2 cm liver lesion - which did not show up on a liver MRI a few months prior. Working through ongoing additional investigations to determine what this 'finding' is.

Over six years ago at 0.13 I had a Ga 68 PSMA which was 'clear' while the Ferrotran nanoparticle MRI identified five suspicious lymph nodes - six confirmed cancerous by salvage lymph node surgery.

This is a tough elusive beast. All the best!