New Study - Men on adt for 6 months- 75% recover Testosterone BUT median time is 18 MONTHS!!!????-Orgovyxx may be different? Yes I Hope??

[JWS13]

New Meta Analysis From Marcap Consortium says :

Men on adt for 6 months -75% recover Testosterone BUT the median recovery time is 18 months !!!

AND THE OTHER 25% -NEVER!??

I TOOK ORGOVYXX FOR 4 MONTHS ???? THEY SAY IT MAY BE DIFFERENT FOR ORGOVYXX??

P.S. Any studies showing return of Testosterone with Orgovyx much shorter than 18 months..

Will Testosterone replacement therapy trigger a recurrence?

Are there meta analysis or trials on this?

All responses welcome and needed...Thank you

62,Gleason 4+3 , ECE, PMSA-no mets, IMRT -20 Tx UCLA

[DrawingSnowmen]

Info on testosterone recovery after discontinuing Orgovyx:

orgovyxhcp.com/efficacy/

Testosterone recovery was evaluated in a substudy of 184 patients who completed 48 weeks of treatment2*

90 days after treatment discontinuation, 55% of 137 men treated with ORGOVYX had their testosterone return to above the lower limit of the normal range (>280 ng/dL) or baseline values1,4*

3% of 47 men treated with leuprolide had their testosterone return to above the lower limit of the normal range (>280 ng/dL) or baseline values 90 days after discontinuation4

This endpoint was analyzed for exploratory purposes without formal testing. The data from the leuprolide arm were not included in the US Prescribing Information for ORGOVYX

[Jac_J]

I think T recovery is highly individual.

After being on Eligard for 2 years, if I stop injecting Eligard my T will be > 800 within 3 months. I doubt that Im alone in my response.

[Murph256]

I’m sure everyone is different. But I’ve been on two ADT vacations. The first time, my T returned to baseline 8 months after my last Lupron shot. The second time, it returned to baseline 4 weeks after my last Orgovyx pill.

[jackwfrench in reply to Murph256]

Hi Murph - may I ask how long you were on Lupron? Did your MO suggest shifting to Orgo or did you ask for it? My MO says Orgo long term results are not documented like Lupron.

[Murph256 in reply to jackwfrench]

I had 2 the month Lupron shots but my testosterone did not recover for 10 months. My MO recommended Orgovyx.

[treedown]

My T returned to baseline 3 months after end of last 3 month Lupron (6 months after shot) and 2 months after stopping Zytiga. T return is different for many but slower return may mean longer vacations so kind of a catch 22.

[jackwfrench in reply to treedown]

Hi - Curious -So was it just one L shot? are you going back to Lupron and Zytiga then? Got my first 3 month Lupron 3 weeks ago and eager about options. How was your SE when you added the Zytiga dosing to the Lupron? Thx

[treedown in reply to jackwfrench]

I was on Lupron and Zytiga for 2 years with initial treatment. After recurrence I am back on it, most assuredly for life or until failure now.

[JWS13 in reply to treedown]

that's a high psa for a 3-4 gl? with 3-4 you need adt? you had recurrence after 44 tx rt?...best of luck to you..

[treedown in reply to JWS13]

Yes it was a high PSA, so they always suspected more disease than the scans showed and PSMA wasn't even mentioned at the time. Axumin was refused by insurance and the Drs said it would not change treatment so no point paying out of pocket. Not sure that part makes sense in retrospect but is what it is.

Thanks and best of luck to you as well.

[bitittle]

My T is 87 one month after 4 months of Orgovyx. Well below baseline. I only have one testicle which may be part of the reason for slower recovery time🤷🏻‍♂️

[Mgtd]

Could you please post the source document for you statement. Might help if we had the whole story to read.

[marlins1]

Just to add to your database. I took the 6month lupron shot. And it did take about 13months to restore Testosterone levels in the 300-400 level.

[Tony666]

one thing these studies never look into is the level of T below which you have symptoms (eg fatigue, hot flashes, brain fog) which is what matters. It’s always castration as defined below a baseline vs full recovery but in reality there is a range to recovery. In other words, what percent recover to 100ng or 150 ng or 200 ng, all below the baseline but still significant. And when is enough to avoid (most or all) symptoms? Unless you know this, these stats make things look worse than they are in reality.