feeling blessed

[thansen535]

Happy to share that no detectable psa score at 2 years post prostatectomy. I feel blessed since I delayed radiation which was suggested by Urologist. Going from 3 month checks to 6 month checks. Hopefully they got it all

Excellent site for info

signing off I hope for good. 🙏🤞

[j-o-h-n]

All? Keep your UserID.....

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 09/02/2023 2:48 PM DST

[thansen535 in reply to j-o-h-n]

Thanks. Will do

[Justfor_]

I read your bio. With unilateral SVI and lymph node invasion the odds of 5 years BCR-free survival is somewhere around 20%. I wouldn't go with 6 months PSA.

[thansen535 in reply to Justfor_]

Thanks Justfor. I will take your advice and stay on 3 months for now. If it starts to show up and over 2, I will proceed with scan. Take care.

[maley2711 in reply to Justfor_]

Can you provide the source for that number....I'd like to check it out!!

[Justfor_ in reply to maley2711]

You permanently challenge the content of my posts. Its your right doing so, but also my right not to waste my time over you. Ignoring one another is the best thing we can do.

[maley2711 in reply to Justfor_]

sorry you misinterpreted my inquiry.......I WAS NOT challenging anything....simply wondered where I could find a nomogram/calculator.= or study that would give me that info you provided!!!!!!!!!!!

[PSAed in reply to Justfor_]

I'm not taking sides in this "spat", but I would very much like to see that source also. On my DX Gl 4+3 =7, PSA 17, N1M0.

I finished my RT Dec 2020 and HT 2 years LUPRON ...last 3-monthly injection... June 2022 . So I'm counting from the month of this September to be 1 year free of ADT in my body. I've had one 6 monthly PSA test already and due the next one this week.

I think your advice to OP to change from 6-monthly PSA test is good advice, although I do not have SV involvement I do have LN involved. As such I am going to ask for 3 monthly PSA tests on my next appointment. It would be helpful if I could give your source to them to strengthen my case. Thanks

[Justfor_ in reply to PSAed]

There are many and (I mean MANY) nomograms, statistical analyses, etc aiming at the BCR free survival after prostatectomy. Roughly, half of them are based on pre-operational parameters, like PSA, biopsy findings, clinical staging, etc and the rest on post-operational ones, like pT staging, ECE, SVI, surgical margins, and early post-op PSA. Yet, there are very few that take into account lymph node invasion (LNI or LNM). This one from Korea does it and estimates the hazard ratios (HR) of SVI and LNI to 3.82 and 2.50:

ncbi.nlm.nih.gov/pmc/articl...

This also allocates half the weight of SVI to LNI:

ascopubs.org/doi/pdf/10.120...

Lastly this one, also from Korea's Seoul National University-Uro-Oncology, quotes HRs for SVI and LNI at 1.861 and 1.470.

journals.plos.org/plosone/a...

Mind you that the OP had also EPE or an additional 1.854 HR, but other papers estimate it lesser than SVI and LNI.

Back to your personal case at this point, all of the above are derived from post-prostatectomy data. I don't know whether they are valid and if yes to which extend for RT + ADT. One gray point is SVI which unless samples are placed under the pathologist's lab microscope no one can tell with reasonable certainty if they have been invaded or not. FYI SVI has 5 sub stages as usually the invasion starts from within the prostate and finds its way up and beyond the seminal vesicle/s, i.e. a) inner only to prostate track, b) outer track but halfway to SV, c) entered the SV, d) occupied the internal part of the SV, e) escaped to the outside of the SV.)

Nevertheless, I posted the links for you to use them as you think appropriate.

Re PSA testing frequency, I for one with unilateral SVI and GS = 4+5 am doing monthly tests 4+ years after LARP.

[PSAed in reply to Justfor_]

Thank you very much for going to all that trouble in your reply. I will certainly study them. Best Wishes.