Does triplet Therapy still work if you've failed Enza?

[CrocodileShoes]

As most posters know the UK doesn't allow for other 'mides' once you've failed Xtandi (as I have done) But I am considering buying Abi from India to add to my Lupron and Docetaxel. Has anyone had success with Abi after Xtandi failure?

Is the triplet therapy likely to work for me?

And does it have to be concurrent? (I'm due to start chemo very soon)

[GP24]

It does not have to be concurrent. In the study many patients had ADT+chemo and Abiraterone got added, not necessarily at the same time as the chemo therapy.

Problem is there is a cross-resistance between Abi and Enza. When Enza fails, Abi will usually work for two to three months only. I suggest that you get your chemo therapy now and then see if the docs recommend to add Abi or Apalutamide after that.

[Tall_Allen]

Triplet has been found to extend the usefulness of Xtandi:

prostatecancer.news/2022/10...

[lcfcpolo in reply to Tall_Allen]

Thank you TA. Very very helpful.Graham

[Finlay66]

The other alternative is Darolutamide perhaps? I think it's reasonable for patients to look for ways to improve the effectiveness of chemo.

Does anyone have a view on this?

[u302000]

I had been ADT which became mCRPC. My on oncologist put me on Xtandi and for four months my PSA continued to rise 0.02 to 69. Being on Xtandi did however qualify me to join the PK subset of the SPLASH trial at Weill Cornell in NYC without having to have had Chemo. Dr Tagawa still has openings I believe. I had my first treatment of LU177-PSMA-PNT2002 the US version of the LU177-PSMA-I&T of the rest of the world. I had bone metastases in ribs, hips, and L4 vertebra. My Ribs had begun to have pain and I was up to Advil twice a day to handle it. Within 4 days after treatment the pain was gone and at three weeks now has not returned! I would highly recommend this next step in place of going through Chemo.

Cheers,

Buddy