triplet therapy

[Jojoteacher]

Hi, I am looking for success stories from people with bone mets on triplet therapy. My husband is on lupron and nubeqa and will hopefully start chemo soon. Gleason 8, mets to bladder, lymph nodes, and pelvis/hips. Thank you.

[Lslal]

I’ve had great success. Check out my profile. Still doing great on Zytiga and prednisone. Exercise of some sort most days and have a trainer 3 times a week. Side effects are minimal except for occasional hot flashes. Reach out if you like to chat.

[Jojoteacher in reply to Lslal]

thank you for your reply. I read your profile and I’m so glad that your husband is doing well. How are you handling everything? Does it get any easier? I’m a wreck emotionally (3 months since diagnosis).

[Lslal in reply to Jojoteacher]

I’m the husband…lol

Yes it gets easier, at least for me. I started my journey with a PSA of 935 Gleason 9, stage 4. My PSa is now 0.01. So the cancer is in a cage, so to speak.

I had 6 sessions of chemo, I get a lupron shot every 3 months and I take my Zytiga and prednisone every day.

Chemo went well except for hair loss but session 4 was the worst when my body almost gave in with the extreme fatigue and loss of taste. But with support of my family I fought through and session 5 and 6 were a breeze.

Since finishing chemo I’m back to normal, so to speak, ha ha, got my strength, play sports, but I also drastically changed my diet.

Im now vegan with some fish. It suits me fine and my works are really showing the benefit.

[Jojoteacher in reply to Lslal]

so good to hear! Thank you for the reply.

[JohnInTheMiddle]

So far after 1 year 100% success on triplet therapy. In my case Firmagon/Degarelix + Abiraterone (w/Prednisone) + six sessions of Docetaxel. My PSA was 1,700. See my profile. PSA now zero for six months. Bone mets to spine and rib cage and apparently even one on the face. Was beginning to press on spinal cord. Apparently have all shrunk. I read a lot of the literature on the trials about triplet therapy. It is the best. You mentioned exercise - I try to do hard exercise 5 or 6 days a week for an hour. The Fitbit shows significant sustained elevated heart rate. From my reading about myokines, exercise maybe as important as the drug therapies you are taking. By the way it took some months after the chemo to recover strength. I could not do a single push-up. I can now do 20 several times a day. I have to be careful though about irreversibly deteriorated vertebrae. I don't have time to make this a better note but I'm cramming all the facts I know in. Managing this thing is a crazy lot of work in a strange way. And I have also realized that I'm fighting three battles. And once you realize this then you can do a better job. (1) metastatic prostate cancer (2) bone health and fracture risk, and (3) cardiovascular risk due to therapies (esp. agonists). Exercise helps all three. I'm big success to you!

[Jojoteacher]

thank you for the post. This gives me so much hope

[Bethpage in reply to Jojoteacher]

Jojo, I replied to your request from the Cargivers group by chat a few days ago. I don't think you've seen? Bethpage

[Jojoteacher in reply to Bethpage]

I’m sorry, I can’t find it. Where is the chat?

[Bethpage in reply to Jojoteacher]

When someone sends me a chat, I receive a separate email from HU so that all I have to do is click on the link and I'm there. If you didn't receive that separate email, then go to your personal profile page and look for the blue rectangle that says "Chat." If you click on it, that will take you to your chat.

[Jerojj]

A mi me detectaron cáncer de próstata metastasico Gleason 5+5, con metástasis Oseas , y psa de 1000 en enero 2022. Empecé con la triple terapia , y tengo el psa en 0,09 y sin nuevos focos. Importante el deporte porque se pierde mucha masa muscular y se coge mucha grasa y peso . También muy importante cambiar la alimentación . Mucho ánimo , el tratamiento Por ahora si está funcionando

[Jojoteacher in reply to Jerojj]

I can’t find it. Can you please add it here?

[Jerojj in reply to Jojoteacher]

que necesitas que añada ?

[j-o-h-n in reply to Jerojj]

to Jerojj, and all I to do is to push the 8 button on the phone. (viva Americano)

I was detected with Gleason 5+5 metastatic prostate cancer, with bone metastases, and a psa of 1000 in January 2022. I started with triple therapy, and my psa is 0.09 and without new foci. Sport is important because you lose a lot of muscle mass and gain a lot of fat and weight. Also very important to change the diet. Good luck, the treatment is working for now

what do you need me to add?

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 06/27/2023 6:57 PM DST

[Jerojj in reply to j-o-h-n]

eso no puede faltar y que la fuerza nos acompañe

[j-o-h-n in reply to Jerojj]

that cannot be missing and may the force be with us.

and mucho trabajo poquito dinero............

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 06/27/2023 9:31 PM DST

[kainasar]

Radiation for mets?

[Jojoteacher in reply to kainasar]

I need to ask the oncologist about that. Last time she said not at this time.

[AlvinSD]

I was diagnosed May 2022 (info in my profile) and started on triplet therapy. Also got radiation in Dec 2022 and Jan 2023. I’m feeling great now and continuing on with Eligard and darolutamide. I have always exercised consistently and continued to exercise throughout all my treatments. I think staying active really helped.

Happy to chat about my experiences if you need it. So many amazing people in this group that are here for you and your husband.

[London441]

I was ‘only’ oligometastatic with lymph mets but otherwise similar. Did triplet therapy in 2019 post RP as a clinical trial. No PSMA pet available to me then so it was considered the ‘kitchen sink’ best offer. Off all treatments for 2 years and PSA still undetectable so far.

You see a common thread in the comments for good reason. Most of my posts and replies on this forum are exercise related. It is the single most important metric in our control by far. Great luck to you!

[dhccpa in reply to London441]

Great results! I didn't realize you were doing that well.

[London441 in reply to dhccpa]

Thanks, hope you’re doing well also. Just ride the wave (whichever one we get) as long as we can.

[Schwah]

I did the triplet therapy about 6 years ago…before it was proven to be so effective. My MO is pretty cutting edge and felt like it was going to work. I’m on my second “vacation”. I’ve also done SBRT to 4 Mets. Pelvis, L-5 and ribs. I too have a trainer and lifts weights three days a week. It helps a lot. I feel great. I also did Provenge a year ago. feel free to private message me for more detail

Schwah

[anony2020]

It is good to know that triplet works. Most reassuring.

Dont mind me. I am a layman. 😊