triplet therapy

[Jojoteacher]

Hi, I’m looking for stories of successful triplet therapy for pc with Mets to lymph nodes, bladder and pelvic bones Gleason 8. I need some encouragement and help in my husband’s and my journey.

thank you

jo

[Tall_Allen]

What is a "success story"? I know several guys who have used it.

[Bret5]

I’m receiving triple therapy with Mets to majority of bones and some soft tissues. . Gleason 10 got past RP in January of this year Jan 2023. PSA of 156 late May. Zoneta for bones. Eligard injection late May. Nubeqa early June. Started chemo with Docetaxel 4 weeks ago. At second chemo session last week Friday, my testostetone was undetectable and PSA was way down to 2.9. MO was thrilled. Said this level of progress is unusual but obviously possible. I do understand I am very early on this journey.

[AlvinSD]

I was diagnosed in May 2022 (Gleason 9 with lymph node and one bone met) and started on triplet therapy. Chemo was summer / fall 2022 then I got radiation in December 2022 / January 2023. My last PSA was <0.1 in April 2023. I’m continuing on with Eligard and Nubeqa (darolutamide), feel great and am very active. Next PSA in August. 🙏🙏

I’m grateful to Tall_Allen who pushed me to push for triplet therapy.

[Jerojj]

llevo con triple terapia desde abril 22. En mi caso está funcionando, tenia psa en 1000, y ahora 0,28. Tengo Mets en hueso pélvico y fémur. El tumor empujaba la vejiga pero con el tratamiento bajo la presión sobre la vejiga. Sobre alimentación , yo he cambiado mucho la forma de alimentarme, ahora : mucha verdura ( sobre todo crucíferas como brócoli o col ), alimentos antioxidantes y antiinflamatorios , poca carne y mucho pescado azul . Mucho deporte de fuerza para evitar la fatiga .

[j-o-h-n in reply to Jerojj]

IN ENGLISH (push 1 for English, push 2 for Spanish).

I have been on triple therapy since April 22. In my case it is working, I had a psa of 1000, and now 0.28. I have Mets in pelvic bone and femur. The tumor was pushing the bladder but with the treatment under pressure on the bladder. Regarding nutrition, I have changed a lot the way I eat now: a lot of vegetables (especially cruciferous fruits such as broccoli or cabbage), antioxidant and anti-inflammatory foods, little meat and a lot of oily fish. Lots of strength sports to avoid fatigue.

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 07/11/2023 3:58 PM DST

[Shams_Vjean]

My MO got me into triplet therapy soon after Dx. I had bone only metastasized diffusely throughout skeleton and skull. Had a follow up scan shortly after finishing chemotherapy with little or no change observed. Bone pain gradually resolved during and after chemo.

Fast forward 1&1/2 years later and my orthopedic doctor wants a scan of my pelvic area done to be certain the cancer lesions haven’t spread to hip where I developed pain from pushing a bit too hard too quickly with walking.

Scan reveals marked healing/reduction of lesions on bones in the pelvic area. Think it’s safe to assume that’s transferable to all my bone lesions.

Over the Top with appreciation for this result, and hoping it’s durable for many more years ahead.

See my profile for more a in-depth overview of my Dx and treatments timeline.

Hope your husband’s response is even better. Best of luck to both of you!

[RoseDoc]

Gleason 4+3, s/p RALP, prostate bed radiation 2015. Last Dec. lung mets found on PSMA scan. Started ADT in Jan with Daolutamide. 6 doses of Docetaxel, last one 5 weeks ago. PSA went to undectable after 4th chemo dose. Lung mets resolved on scan 2 weeks ago.

Will continue on the ADT but my doc very pleased and optimistic.

[LakeT]

Diagnosed March 2022. Success so far with PSA undetectable. Still early days but I couldn’t have how’d for a better result. Based on what I have read on this group I have added resistance training 3 times per week.

[JohnInTheMiddle]

Triplet therapy a year and a half now. Just had my anniversary full on scans and a lot of lesions have diminished. PSA is zero. No pain for almost a year.

Specifically Docetaxel, Abiraterone, Firmagon.

It used to be you try one therapy after another and each one would fail. Then the really big trials showed that if you pile up everything at the beginning you get a much better result.

I'm also on sort of a Keto low carb diet. And I'm up to 5 hours of exercise per week. I have to be careful because I have metastases-compromised vertebrae up and down my spine.

But whereas a year ago I was moaning on the floor at night because of a "back ache" (in other words yet another surprise diagnosis of prostate cancer because of prejudice against PSA testing), eventually diagnosed with Gleason 9 and a PSA of over 1700, I'm now in sort of good health. Two days a month the ADT gives me kind of a flu and a fever with a sore stomach. And quite tired so that I am now newly on an amphetamine.

Another success story though. If your husband has the opportunity to do triplet therapy, from my reading, and not only my personal experience, this is the best thing.

Big success for you and your husband!

[Gpatwice]

I completed triplet therapy , Docetaxel, Nubeqa and Lupron in November 2022. Mets to occipital bone, thoracic spine, lumbar spine, and sacrum bone. PSA results March 2023 and June 2023 were both undetectable. Diagnosed Gleason 8 in 2014. I am currently castrate sensitive, I receive 3 month Lupron injection and I take NUBEQA tablets daily. Staying positive, prayer, keeping the faith, exercising, diet and loving support from wife of 35 years and my children and grandchildren keep me going. Love and Endure.

[JohnInTheMiddle]

One more comment to add in addition to my earlier comment. Not all PC "enjoyers" (let's not say "victim" 😃) get offered Triplet. If you have too much damage or you are not strong enough (e.g. for chemo) you won't be offered it. Happens all the time.

That your husband has been offered Triplet Therapy speaks well of your jurisdiction (Triplet is also not yet "standard of care" in many places in the world) AND that the doctors who have met to consider a plan for your husband believe he is strong enough, with good prospects for benefitting from this therapy. Bravo!