Just received PSA results from 4th Infusion of LU-177 I&T, as part of the Eclipse Study. It increased from 0.1 to 0.2.
PSA baseline was 2.0.
Following 1st infusion PSA dropped to 0.3.
Following 2nd infusion no PSA was taken.
Following 3rd infusion PSA 0.1.
Following 4th infusion PSA 0.2.
Having PSMA PET Scan 8/22 & CT & Bone Scans 8/23/23. Will know more then.
Am I panicking, thinking that LU-177 is failing?
Any other warriors have similar fluctuations?
My psa was 138 before my first shot after the 3rd it was down to 11. I haven't had labs since my last shot a week ago.
That's quite remarkable! Would you mind sharing your history?
I had two shots years ago, PSA was 19.6 reduced to 2 after first shot & 1.6 after second then they would not ley me have the third after they found out I had not been on ADT recently.
After two years it was back to 19 again.
That's a shame because in the Eclipse trial you have to be on ADT. You might want to try it again, if you can?
How did they find out you had not been on ADT?
My GP recommended me in the first place & I started treatment without any questions asked, until somebody did ask me, then no third treatment.
Like they have the power over life & death.
Wow, looking at your bio you have battled this disease longer than most! Our goal is to survive long enough until they come up a "real" cure!
That is the plan, but it would be better if they could come up with that magic bullet or pill or whatever.
Lu-177 has different SE for different people I noticed, some people do well for years & some not. I developed stomach pain & my right knee had pain after the second infusion but PSA took two years to come back.
I had similar results. Initially responded but not durable. Went to Johns Hopkins met with Sam Denmeade, doing a self administered BAT protocol. So far with positive results and improved quality of life.
DH’s PSA fluctuated 4 points from 27 to 31 between 4th and 5th infusion. After 5th infusion it decreased to16.7. Could Fluctuation be from dead PSA being released into bloodstream? Wishing you the best
I just had treatment number 5 and have had a slight increase in psa after each infusion.
That's what we are hoping is happening, because per our Doc. the LU 177 continues to work for quite a while! Best of luck to you!
I am about to start treatment. 6 scheduled. My oncologist says we will not follow PSA because it is not a true reflection of cancer activity during this treatment. He will get a PSA and a PET scan after the 4th dose and decide if we go further. My PSA is rising 1 point per month and I am just over 20 now. Docetaxol with huge side effects last year.
Yes, the Eclipse team said I should get PSMA PET scan to see what's going on. Unfortunately the study only provided for one PET scan, at the beginning & only CT's & Bone Scans afterward. I just about finished with the trial and primary care MO has me scheduled for one. Hopefully, a scan for you will show better results!
Yep, time to progression on this trial is based on CT and bone scans. They don’t care about PSA at all. I am now switching to 12 week intervals. So far, no evidence of progression for me.
I see you started the Eclipse in February. So did I. Would you mined revealing your PSA numbers. After next week's CT & Bone Scan I will switch to 12 week intervals, too!
I was just under 4 last month. I was 21 when I started in February.
So are you following up with your original MO/URO or are you just going with the Eclipse Scans, in the future?
Did you have any pain with your lesions. I am having a burning/stabbing pain at some of the old sites. We are speculating that it could be the voids left by the dead cancer cells in my spine & compression of surrounding nerves? Once regrowth of bone occurs, in those areas, the nerve pain with dissipate, we hope?
I didn’t have any pain actually. I had once suspicious spot on L6 but that seems to have resolved. I will follow up with my new Oncologist after my scans in October. My current MO is the new President/CEO of the Prostate Cancer Foundation so he is giving up his patients. For now I will continue my monthly Lupron and monitor my PSA.
I am not an expert but that slight fluctuation doesn't seem to be anything to worry about yet; especially at that number and variation.
I had my 4th infusion 3 weeks ago. Before starting Pluvicto PSA was 68.37. Had labs today and PSA is 9. next infusion in three weeks.
All the best to you stay strong.
Yeah, hope you are right and the LU177 is continuing to do it's job and staying ahead of the cancer repopulation attempt!
Best of luck with the additional infusions.
After my 3rd I stared developing back pain. We theorize that before the regrowth of bone, in my spine, etc., the nerves may be affected. This should pass eventually, with new growth, but I am now on Gabapentin (Neurontin).
Update. My PSA has started to rise but sufficient progression is not showing up in the scans. For failure per the trial, they need to witness two NEW ares of metastasis. So I continue forward, with monthly Lupron and quarterly scans. I discussed with my current onc and spoke to Dr. Ryan of PCF, and both agree cont8nuing forward is the best option until we see measurable progression. I am a year in so far which seems good to me.
I had good results on Firmagon now & hopeful of T2 one day.
Were you already on ADT when you had the intake PSA of 2? If so then the decline is likely due to the Lu treatments. You have a 95% PSA response down to 0.10! The repeat PSMA PET is the right way to go and compare to the intake one. Hopefully confirm the PSA results. Good luck with the back pain.
Yes, I was on ADT. I was on Erleada, also, for 6 months before it failed.
I am in conversations with a doc in New dehli india. For the treatment , Lu 177. 
Lu-177 waiting for treatment...
2nd LU 177 PSMA injection
Any advice on LU 177?
