PSMA PET and PSA

[Simonapo]

Hi, my Dad was diagnosed with PC 2 years ago, had Radiation and has been on Lupron, Abiraterone and Prednisone ever since. Recently he had a PSMA PET that reads:

“The prostate gland has decreased in size from 6/6/2022, now spanning 3.6 cm in transverse dimension, previously spanning 4.1 cm in transverse dimension. There is persistent abnormal radiotracer activity centered in the left aspect of the prostate gland which measures a maximal SUV of 10.0, previously measuring a maximal SUV of 19.1.

Faint radiotracer uptake in the right lateral sixth rib, which is not elevated relative to background hepatic uptake at this time, and without underlying CT correlate, indeterminate, which may potentially reflect false positive uptake.

No PSMA expressing lymphadenopathy nor evidence of PSMA expressing visceral metastatic disease at this time”.

The oncologist at COH said it looks good, however for the first time in these 2 years there was a slightly increase in PSA readings from 0.034 to 0.037.

Should I be concerned? Also the doctor is recommending to stop Abiraterone at 2 years, I am reluctant to do that. Any advice is greatly appreciated.. Thank you so much.

[FormulaRob]

A number of details sound familiar to my fathers. MRI and bone scan showed no distant spread and he did these tests twice each. Unfortunately we did not have access to PTScan so we are hopeful that the these more basic scans caught it all.

Next month is his 6 month follow up after he finished radiation. No idea what to expect but praying for good news

No answer for you here but I will be following your posts and just want to wish good luck to you and your dad. Having a parent go through something like this is devastating for us kids too . I like you invest a lot of time and research in hopes of helping in any way possible. I hate that this is our reality but sometimes helps a tiny bit knowing there are others in the same situation

[Simonapo in reply to FormulaRob]

Thank you so much, yes is very hard on us as we love our parents very much, best of luck to your dad as well.

[Radtech40 in reply to Simonapo]

This is actually pretty good news and thats not a significant rise, I'm in the worry boat with my dad as well but this may make you have some hope. My father started in 2016 with a psa of 1280 stage 4 distant mets in the bones (skull, ribs, sternum, shoulder, femur, pelvis) and lymph nodes, this May was his 7 year mark from being diagnosed as he turned 90 with stage 4 and his psa is currently .056!!! We LOVE our parents and dont want them to suffer, its tough, and dad has bounced around on a few different pills when one stops working, he takes another , etc but his bone mets are stable and psa is still low, I've never stopped worrying with each lab and each scan, but there are so many treatments now, I am very thankful to the 7 years and how ever many more God will give us with him. Good luck to you and your family.

[Simonapo in reply to Radtech40]

Hi Helen, so good to hear from you and so glad that your Dad is doing well, I sent you few messages awhile back to check how things are going, maybe you didn’t receive them, anyway so happy all is good. 🙂

[Hidden]

The .003 difference in readings is most likely a testing variation.

[Simonapo in reply to Hidden]

I am hoping so, thank you so much

[Tall_Allen]

That's not a "slight increase", that's "no increase." And the PSMA results are excellent.

[Simonapo in reply to Tall_Allen]

omg Thank you so much Allen, I highly respect your opinion, you made my day, thank you for your knowledge and help.

[earstohear]

I have been on Abiraterone, Prednisone, and Lupron for nearly six years. PSA and Testosterone have been undectable for years. Feeling fine. Now using 250mg Abiraterone with a low fat diet. Monthy lab tests all look fine.

[Simonapo in reply to earstohear]

Thank you so much, so glad to hear that Abiraterone and Prednisone are still working after almost 6 years, that’s amazing, thank you and best of luck

[BigCDrugSurfin]

Congrats to your dad! I was diagnosed s4-metastatic thanksgiving '22. psa was ridiculous . basically same protocol as your dad, just had 2nd lupron injection, psa has declined quickly to 1, and I feel great. Looking forward to those low-low psa readings! Breathe deeply, and be in gratitude :-). My diagnosis was a great gift for reflection and clarity. I am grateful for the experience and have met so many wonderful people. Take care!

[Simonapo in reply to BigCDrugSurfin]

thank you so much, best of luck to you too

[Fermented in reply to Simonapo]

I have nearly completed two years, identical therapy as your dad and PSMA Petscans similar. My UCSF PC specialist has recommended I take a "vacation" from intensive ADT at end of second year, monitor PSA unless rises above 0.2. Refer you to the STAMPEDE trial. No guarantees of complete remission, but I am 75 and need a break from the hormone treatments. All of the radiation, Lupron,aberaterone have worked for my stage 4 bone mets, but every person is completely different and responds differently. Wish you and your father well, but sounds like therapies are working.

[Simonapo in reply to Fermented]

thank you so much, I totally understand the need for a break, wish you well too 🙂

[j-o-h-n]

You remind me of my blow up doll.....(related?)

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 07/13/2023 7:41 PM DST

[Simonapo in reply to j-o-h-n]

love your humor John, thank you for bringing a smile 😊