My dads PSA is climbing, Olaprib next?

[StayingSTRNG]

Hey everyone!

If you have seen my previous posts, my dad had a PSA come back double a little while ago and the MO failed to mention anything to us about it. Thanks to all your insight, we got in contact with them with our concerns.

6 weeks later, we are told his PSA (previously 1.68? 3.44) is now 11 after 6 weeks from his last test. They have suggested that the Erleada is not controlling the cancer and to switch to Olaprib. This is the first we have hear about this, but his biopsy from almost 1 year ago TODAY, but he has the BRCA1 mutation.

No mention of a PSMA scan but we will have new scans done in a few weeks as they said that the previous scans show no change (new reductions or additions). Do you think we should push for the PSMA? Would it be helpful? Any other helpful advice would be great!

And thank you all for giving me the push to push them, otherwise we would be worse off!

[Tall_Allen]

Olaparib sounds like a good choice, perhaps combined with Zytiga or Xtandi:

prostatecancer.news/2022/06...

In tracking progression, it is important to continue using the same scan that was used before. If that was a bone scan/CT, he should continue to have that. I don't understand how a PSMA PET scan will change his therapy.

[StayingSTRNG in reply to Tall_Allen]

I’m not sure either! People on here just mentioned it before so I don’t know too much about it.

My dad was on Zytiga before but had to stop due to side effects, hopefully acts do though

thanks!

[Tall_Allen in reply to StayingSTRNG]

People are just trying to be helpful, but sometimes they don't understand the situation.

[StayingSTRNG in reply to Tall_Allen]

I see, that’s fair. Thanks for the insight!

[Mw921000000 in reply to Tall_Allen]

hey TA, can olaparib be taken in combo with either Zytiga/xtandi if you have become resistant to one or both of those drugs?

[Tall_Allen in reply to Mw921000000]

It can be used with the one that has not been used.

[bandgeek]

If you have any doubts.....get a 2nd opinion!!

[StayingSTRNG in reply to bandgeek]

I think the plan makes sense, I think I just get impatient due to the waiting. I took 6 weeks to get the answer I already knew, and he has to wait another month before starting new medication. Maybe that’s the norm! But he’s in pain so it feels like an eternity