The FDA today approved Veozah (fezolinetant) for women's hot flashes during menopause. It acts on the thermoregulatory mechanism in the brain. I would expect it to work on men taking ADT too, although it has not been proven. I hope that Medicare/Insurance will cover it in men.
New hot flash drug approved - Advanced Prostate...
New hot flash drug approved
Thank you!
Sounds great! I've been on Eligard for 4-1/2 years and still get hot flashes. Not as bad as when first started.Thx
It may be approved by Medicare based in medical necessity.
This drug may cause some undesirable side effects and also interacts with CYP1A2 inhibitors.
accessdata.fda.gov/drugsatf...
"Concomitant use of VEOZAH with drugs that are weak, moderate, or strongCYP1A2 inhibitors, increase the plasma Cmax and AUC of VEOZAH [see Clinical Pharmacology (12.3)]. VEOZAH is contraindicated in individuals using CYP1A2 inhibitors."
go.drugbank.com/categories/...
I will keep dealing with my nocturnal hot flashes using the remote controlled fan close to my bed.
"Neurokinin-3 (NK3) receptor antagonists like Fezolinetant have been found to dose-dependently suppress luteinizing hormone (LH) secretion, though not that of follicle-stimulating hormone (FSH), and consequently to dose-dependently decrease estradiol and progesterone levels in women and testosterone levels in men. As such, they are similar to GnRH modulators, and present as a potential clinical alternative to them for use in the same kinds of indications. However, the inhibition of sex hormone production by NK3 receptor inactivation tends to be less complete and non-castrating relative to that of GnRH modulators, and so they may have a reduced incidence of menopausal-like side effects such as loss of bone mineral density."
This is good news. Thank you.
I've been getting severe hot flashes, full body sweats hourly. Dr has tried Paxil and Effexor without effect. Hope I can try this next if I can get it under the suggested price of $550/month
Same here. I keep hearing that I’m more the exception than the rule. All I know is it’s barely worth living with how bad I get these. I’m on this medicine with inconclusive results. I’ve actually thought about doubling the dose to see if that worked. To date the only relief I get is with the use of estrogen gel. Without that, I probably would have gave up the fight. Good luck Huzzah, I’d love to hear how you’ve been doing with this as well.
My friend is getting great results with Veozah.
I Finally started Acupuncture, something my MO suggested from the get go. I thought good old Drugs were the best option.
OMG, it has done wonders for me! I’m sure the practitioner has a lot to do with it. I live just NE of Atlanta which has a large Asian population. I talked to some folks and started going to a great practice. Has done wonders.
Why do you think it binds to estrogen receptors? It binds to NK3 receptors.
Thanks for the info, I have a friend that has had problems with this since she started menopause.
"I hope that Medicare/Insurance will cover it in men."
All we have to do is go into a Medicare office and show them our tits....
Good Luck, Good Health and Good Humor.
j-o-h-n Saturday 05/13/2023 6:14 PM DST
What can you tell me about your friend that is taking Veozah