ChatGPT passes the Bar Exam, US Medical License Exam, and Wharton’s MBA Final Exam. For comparison, the US Medical License Exam normally requires four years of medical school and then a few more years of residency to pass. ChatGPT did it in two months.
GPT-4, OpenAI’s newest model released last month, then beat us humans by 75% or more on a range of other exams: from the LSAT and the GRE, to the SAT and the AP Math exam.
An AI system defeats top doctors in tumor diagnosis competition in China. The AI correctly diagnosed 85% in just 18 minutes, compared to top neurologists who achieved 64% accuracy in 50 minutes. Soon, our best diagnosticians are going to be AIs.
AI designs a potential cancer drug in 30 days. Researchers used AlphaFold and the drug discoveryplatform Pharma.AI to design and synthesize a potential drug to treat hepatocellular carcinoma (HCC), the most common type of primary liver cancer.
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Scout4answers
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Here are the 5-year survival rates for prostate cancer with each of the following stages:
Stage 1: The 5-year survival rate for prostate cancer at this stage is close to 100%. In fact, many men with stage 1 prostate cancer may not even require treatment, and can instead opt for active surveillance to monitor the cancer and ensure it is not growing or spreading. (Source: American Cancer Society)
Stage 2a: The 5-year survival rate for prostate cancer at this stage is also very high, with an estimated 99% of men surviving for 5 years or more after diagnosis. (Source: American Cancer Society)
Stage 2b: At this stage, the 5-year survival rate for prostate cancer drops slightly to around 95%. However, this is still considered a relatively favorable prognosis. (Source: National Cancer Institute)
Stage 2c: There is no specific stage 2c for prostate cancer as per the TNM staging system. Some sources may use this staging, but it is not widely recognized. (Source: National Cancer Institute)
Stage 3a: The 5-year survival rate for prostate cancer at this stage is around 90%, indicating that the cancer has started to spread beyond the prostate gland but is still localized to nearby tissues and organs. (Source: American Cancer Society)
Stage 3b: The 5-year survival rate for prostate cancer at this stage drops to around 72%. At this stage, the cancer has spread to nearby lymph nodes, indicating a higher risk of metastasis. (Source: American Cancer Society)
Stage 3c: There is no specific stage 3c for prostate cancer as per the TNM staging system. Some sources may use this staging, but it is not widely recognized. (Source: National Cancer Institute)
Stage 4a: The 5-year survival rate for prostate cancer at this stage is around 29%, indicating that the cancer has spread to other parts of the body, such as the bones or other organs. (Source: American Cancer Society)
Stage 4b: The 5-year survival rate for prostate cancer at this stage drops further to around 15%. This indicates that the cancer has spread extensively to other parts of the body and may be difficult to treat. (Source: American Cancer Society)
Stage 4c: There is no specific stage 4c for prostate cancer as per the TNM staging system. Some sources may use this staging, but it is not widely recognized. (Source: National Cancer Institute)
It's important to note that survival rates are just estimates and can vary widely depending on a number of individual factors, such as age, overall health, and the specific characteristics of the cancer. It's also worth emphasizing that survival rates are not the same as cure rates and that some men with prostate cancer will survive for much longer than 5 years, while others may not survive as long as expected.
let’s see what it knows about optimal treatment for 3b …
Would you ask it “what is the optimal therapy to persue following radiation and adt + aberaterone when those therapies are finished if a person has stage 3b prostate cancer to extend time to OS?
The optimal therapy to pursue after radiation therapy, androgen deprivation therapy (ADT), and abiraterone for stage 3b prostate cancer to extend overall survival may depend on various factors such as the patient's overall health status, previous treatments, and the extent of the cancer.In general, there are several options available for extending overall survival and improving outcomes in patients with advanced prostate cancer, including:Chemotherapy: Chemotherapy drugs, such as docetaxel or cabazitaxel, can be used in patients with advanced prostate cancer that has spread to other parts of the body. These drugs can improve overall survival and quality of life.Immunotherapy: Immunotherapy drugs, such as pembrolizumab or nivolumab, can be used to stimulate the immune system to fight cancer cells. These drugs are typically used in patients with advanced prostate cancer that has not responded to other treatments.Targeted therapy: Targeted therapies, such as enzalutamide or apalutamide, can be used in patients who have developed resistance to ADT and abiraterone. These drugs can help to improve overall survival and delay disease progression.Radiopharmaceutical therapy: Radiopharmaceutical therapy, such as radium-223, can be used to target bone metastases in patients with advanced prostate cancer. This therapy can help to reduce pain and improve overall survival.Clinical trials: Clinical trials may be an option for patients who have exhausted standard treatment options. These trials can provide access to new therapies that are not yet available to the general public and may offer the potential for improved overall survival.Ultimately, the choice of therapy will depend on a range of factors, and it's important to discuss all available options with a healthcare provider to determine the most appropriate treatment plan to extend overall survival.
…’ to extend overall survival may depend on various factors such as the patient's overall health status’
Which is the crown jewel of ‘various factors’.
All the current medical treatments are either modernized antiques or emerging and still in the ‘horse and buggy’ stage. All of them have efficacy and duration of effectiveness that vary wildly. All are a significant challenge to ‘the patient’s overall health.’
Yet the average 3b patient is in poor overall health already by the time they get there. Your best shot at extending OS is to make the difference that is in your control.
What app? I don't think there's an official openai.com (the official ChatGPT site) app. All the apps on the App Store that I saw were from third parties.
I use open.com directly in the browser, no third party middlemen to track my data and queries.
I also use a great Apple Siri Short Cut that goes to ChatGPT3 for Siri queries. Really good stuff, and again, no 3rd parties involved.
Also, I saw someone mention they were limited in the queries. I've never hit a limit with it yet directly on their website.
The reply from GPT-4: I am not a doctor, but I can try to provide you with some general information about treatment options for advanced prostate cancer. It is important to consult with a healthcare professional for personalized advice tailored to a patient's specific circumstances.
When hormone therapy (ADT) and radiation therapy, along with medications like abiraterone, are no longer effective for stage 3B prostate cancer, a patient's oncologist may consider several other treatment options to manage the disease and extend overall survival (OS). These options may include:
Chemotherapy: Common chemotherapy drugs used for advanced prostate cancer include docetaxel and cabazitaxel. These medications can help shrink tumors and slow the progression of the disease.
Immunotherapy: Sipuleucel-T (Provenge) is an immunotherapy option that may be considered for some patients with advanced prostate cancer. This treatment uses the patient's immune system to help fight cancer cells.
PARP inhibitors: For patients with specific genetic mutations (such as BRCA1/2), PARP inhibitors like olaparib and rucaparib might be effective in slowing down the progression of the disease.
Radium-223 (Xofigo): This is a targeted radiation therapy for patients with advanced prostate cancer that has spread to the bones, causing pain. Radium-223 helps relieve pain and may extend survival in some patients.
Enzalutamide (Xtandi) and apalutamide (Erleada): These are androgen receptor inhibitors that can be used to treat advanced prostate cancer when other hormone therapies have stopped working.
Supportive care: Supportive care focuses on managing symptoms and improving quality of life. This may include pain management, palliative radiation therapy for symptomatic bone metastases, and other supportive treatments.
It is essential to discuss the appropriate treatment options with the patient's oncologist, who can provide personalized recommendations based on the patient's medical history, overall health, and specific cancer characteristics.
so I’m trying to determine what stage i am. I thought i was stage4a, but?
Any ideas?
4 different lymph mets in pelvic, one met in lymph clavicle, one met in mediastinum lymph. RP, pelvic radiation, 1 year so far on Orgovyx and darolutamide. PSA WAS 15 before starting ADT/ARi.
I don't know how to connect the dots but would hope AI could lead to a better methodology for clinical trials. Also would like to see AI read scans, biopsies, etc and present logical courses of action. It would be cool to see it develop a BAT predictive model as well as customizing selective Doublet, triplet therapies.
to a certain degree current research is done in silos and no one is assembling all the data and looking at it from 10,000 feet. Thinking about combos that could be synergistic .
My limited understanding is that there are thousands of pathways that a cancer can take to perpetuate itself. We need a technology that can take a global view of all the pathways and find a solution to dramatically slow or stop cancer’s progression.
Yes, but even more ideally, it would aggregate info specifically for the body and situation of the person asking the query - taking into factor the person's current state of health, co-factors, nutrition, exercise, stress level, etc.
With these large model language AI‘s, it’s all about the query that you construct. It’s not like learning a new language, but you have to think about what parameters you want it to consider and building them into your question.
So you’d add something into your question like “ For a 70 year old man with stage four prostate cancer, well-controlled type 2 diabetes, who eats a vegan diet and exercises vigorously two hours per day, blah blah…”
GPT-4 at your service: Yes, you are right. Cancer is a complex and heterogeneous disease, involving numerous genetic, epigenetic, and signaling pathways that can vary significantly between patients and even between different cancer cells within the same tumor. This complexity is a major challenge in the development of effective cancer therapies.
To tackle this challenge, there are a few approaches that researchers are employing to develop more effective therapies:
Multi-omics analysis: This approach combines the analysis of various types of biological data (genomics, transcriptomics, proteomics, metabolomics, etc.) to provide a more comprehensive view of the molecular processes underlying cancer. By integrating these diverse data sources, scientists can better understand the complex interactions and dependencies between different pathways and identify potential therapeutic targets.
Artificial intelligence and machine learning: AI and machine learning techniques are increasingly being applied to analyze the vast amounts of multi-omics data generated by cancer research. These techniques can identify patterns and relationships in the data that would be difficult or impossible for humans to detect, leading to the discovery of novel therapeutic targets and the development of personalized treatment strategies.
Systems biology and computational modeling: Systems biology aims to understand the behavior of complex biological systems, such as cancer, by constructing computational models that simulate the interactions between the various components of these systems. By iteratively refining these models based on experimental data, researchers can gain insights into the mechanisms driving cancer progression and identify potential strategies for intervention.
Drug combination therapy: Instead of targeting a single pathway, drug combination therapies target multiple pathways simultaneously, which can lead to more effective cancer treatments. This approach can help overcome resistance to therapy, as cancer cells are less likely to develop resistance to multiple drugs targeting different pathways.
Immunotherapy: This approach harnesses the power of the immune system to attack cancer cells. Immunotherapies, such as immune checkpoint inhibitors and CAR-T cell therapy, have shown promising results in the treatment of certain cancers by modulating the immune system to recognize and destroy cancer cells.
Despite these advances, it is essential to continue investing in cancer research to develop even more effective therapies and strategies to combat this complex disease.
Be both. This is great stuff, but if the "singularity" ever arrives and the AIs become sentient, we're all toast when they go The Matrix or Terminator SkyNet on us. 😀
With that in mind, don't swear at Siri, or kick your Roomba robot for missing a spot. LOL
I have not used google search for about a month, relying solely on chatgpt-3.5 and 4.
Here is one I did:
Question
I had a prostate cancer metastisis on my pubic ramus. The metastisis may have been a false finding due to my having a hairline crack at that same site due to a bycilcing accident. What method at this point, five years after standard of care treatment, could be used to verify it was a metastasis?
Answer:
I am not a doctor, but I can try to provide you with some general information. It's important to consult with a healthcare professional for personalized advice.
Five years after standard of care treatment for suspected prostate cancer metastasis, there are a few methods that could potentially be used to verify if it was indeed a metastasis or a false finding due to the hairline crack:
Imaging studies: Advanced imaging techniques such as PET/CT scans, MRI, or bone scans can be used to evaluate the area of concern. These scans can help visualize any changes in the bone and provide insights into whether the area has healed, if there is any recurrence, or if there are any new findings.
Biopsy: If there is still an area of concern in the pubic ramus, a biopsy could be performed to obtain a tissue sample for further analysis. A pathologist can examine the tissue under a microscope to determine if there is any evidence of cancer cells or if the finding was due to the hairline crack.
PSA testing: If you had prostate cancer, regular PSA testing can help monitor for any signs of recurrence. A rising PSA level may suggest the presence of cancer cells and warrant further investigation.
Medical history and physical examination: A thorough review of your medical history, including the circumstances surrounding your initial diagnosis and treatment, can provide valuable information. A physical examination by a healthcare professional may reveal any new or concerning findings.
It's essential to discuss your specific situation with a healthcare professional, such as a urologist or oncologist, who can provide personalized recommendations based on your medical history and current health status.
I got tired of it always saying consult a medical professional, so I started stating I was a medical doctor, or oncologist. It let up a little bit with that.
What foods or supplements are associated with an increased risk of prostate cancer progression?
Answer:
There are several foods and supplements that have been associated with an increased risk of prostate cancer progression. Here are some of them:
Red meat: Consuming large amounts of red meat, particularly processed meats, has been linked to an increased risk of prostate cancer progression. This may be due to the high levels of saturated fat and carcinogens found in these foods.
Dairy products: Several studies have found that men who consume high levels of dairy products, particularly high-fat dairy products, have a greater risk of developing and progressing prostate cancer.
Saturated and Trans fats: High levels of saturated and trans fats found in fried and fast food have been linked to an increased risk of prostate cancer progression.
Calcium supplements: Some studies have found that men who take calcium supplements may have a higher risk of developing advanced prostate cancer. It is recommended that men obtain calcium from their diet rather than supplements.
Alcohol: Excessive alcohol consumption has been linked to an increased risk of prostate cancer progression.
It is important to note that the relationship between diet and prostate cancer progression is complex and still being studied. It is recommended that men with prostate cancer speak with their healthcare provider and a registered dietitian to develop a personalized dietary plan that takes into account their individual needs and preferences.
Until someone convinces me otherwise an overhyped tech that still suffers the limits of software programming and those who do the programming. Prefer Google or pubmed search results. Who cares if AI does better at test-taking??? Some smart people are warning of dangerous runaway technology???? The internet is certainly not all good for our societal health? alot of inflated egos at the top of tech industry!!!
Im with you, Elon Musk is warning of the dangers of this runaway technology as the are no controls on it, anyone can do anything they want, Elon warns that in the near future AI might dicide there's no use for human beings at all, so what will be the use in fixing them, people don't realise what there play with, sorry its off subject but this is dangerous stuff.
Hello Scout4answers, After posing five free questions to ChatGPT regarding various aspects of prostate cancer therapy and receiving surprisingly reasonable responses I decided to subscribe for a month. It has helped me narrow down and save time doing searches. Instead of spending hours going through 500+ articles have I narrowed it down to <30 minutes, as an example. It should be noted though that I have obtained some responses that didn’t make sense or were wrong so you have to verify what you get. They should make an AI medical search engine that provides references to the statements it makes. Cheers, Phil
It will provide references if you ask it to in your query.
“Write a paragraph about the effectiveness of CyberKnife for prostate cancer and provide references”
CyberKnife is a type of radiation therapy that has shown promising results for the treatment of prostate cancer. It is a non-invasive treatment option that delivers high doses of radiation directly to the tumor site with extreme accuracy, sparing surrounding healthy tissue from damage. This precision is achieved through the use of advanced imaging techniques and robotic technology that can adjust the radiation beam in real-time to track the movement of the prostate gland during treatment.Studies have shown that CyberKnife can achieve high rates of disease control and overall survival while minimizing side effects such as urinary incontinence and erectile dysfunction. A systematic review and meta-analysis of 14 studies involving 1,816 patients found that CyberKnife had a 5-year biochemical recurrence-free survival rate of 85.6% and a low incidence of gastrointestinal and genitourinary toxicity (1).Another study compared the outcomes of CyberKnife and traditional radiotherapy in 370 patients with localized prostate cancer and found that CyberKnife had a higher rate of biochemical disease-free survival (90.2% vs. 78.1%) and lower rates of grade 2 or higher genitourinary and gastrointestinal toxicity (2).In conclusion, CyberKnife is a highly effective and safe treatment option for prostate cancer patients, offering high rates of disease control and minimal side effects.
References:Lei S, et al. Systematic review and meta-analysis of CyberKnife for treating localized prostate cancer. Oncotarget. 2017;8(47):83149-83161.King CR, et al. Stereotactic body radiotherapy for localized prostate cancer: pooled analysis from a multi-institutional consortium of prospective phase II trials. Radiother Oncol. 2013;109(2):217-221.
ChatGPT isn't stand alone AI. It uses the internet to learn. BARD is google's project. It doesn't use the internet. It would be interesting too posit the same question to both AI engines and see the output.
ChatGPT wrote that post, right? I mean, how can anybody believe anything they read (or see, or hear) anymore? Do a search for any of the terms used, and you find plenty of sources...or "sources." Are the sources real, or are they ChatGPT? Even if your post is real (i.e., written by you), are the sources real? AI is self-referencing and self-replicating -- I think, therefore I am. The possibilities are endless, reality is malleable. (Aussie mayor sues ChatGPT over made-up news story. ChatGPT used to trick people into downloading fake ChatGPT text generator. Nick Cave slams song written by ChatGPT "in the style of Nick Cave." Pope Francis in a white puffer coat.)
It's Nineteen Eighty-Four: Big Brother is firmly in control and can make us believe anything he wants us to believe. 2+2 = 5. Canada has invaded us so we have to bomb Toronto. The horse is out of the barn, the cat's out of the bag, Pandora has escaped her box because somebody left the lid open. We can't go back (until ChatGPT tells us time travel is real).
QAnon created reality out of thin air for millions of people without using AI. Ask yourself: Are we ready for this?
I am an actual living human being (I think) and I'm 99.99% sure I wrote this message.
CBS 60 Minutes had an excellent segment on AI with Google’s Bard developer. What they are doing and concerns about how to roll it out, safely and minimizing disruptions. Goes way beyond Chatbots! Weaponization and criminalization cannot be far behind. Worth paying close attention to. BTW what happened to IBM’s Watson? Paul (written by human only)
So I’ve got a very mean-spirited and nasty troll on this site responding to my posts and sending some really disturbed messages by DM.
I thought it would be entertaining to run a couple of his posts through ChatGPT and ask it to evaluate his/her writing skills. I absolutely love and agree with its assessment:
The writing skills of the author of this text are extremely poor and inappropriate. The use of derogatory and offensive language, insults, and threats towards the recipient is completely unacceptable and unprofessional.
The author's writing style is also very informal, with no clear structure or purpose to the text. The lack of proper punctuation, capitalization, and grammar make it difficult to read and understand the intended message.
Moreover, the author's use of profanity, slurs, and violent language demonstrates a lack of respect for the recipient and is not suitable for any form of communication, particularly in a professional or formal context.
In summary, the writing skills of the author of this text are wholly inappropriate and should not be emulated. The use of derogatory language and threats towards others is never acceptable and can have serious consequences.
Ah mate, if you've got a nasty troll on here you should make them known so we can all avoid them, since we've all got aPC i thought that made us adults and not children, we should all be able to put different views across and have discussions without being attacked even if we disagree, to me, the world would be a very boring place and we all agreed on everything, yeah i would have to agree with the response you got from your question also 👍
I haven’t investigated the AI thing yet, but did see an article where they asked one of the AI engines some test questions, and it was obvious that the AI had all of the political viewpoints that those above us want it to have. And it took the same viewpoints on the hot button sciency stuff.
Another one I came across was a young person that had a long conversation with one of the AIs and was convinced to commit suicide to save the planet.
AI and any other new tools are a welcome additions in the search for cancer strategies, treatments, and cures.
The old approaches took a substance and applied it to cancer cells and normal cells. First in the lab, if it killed the cancer and not the normal cells it progressed on to more testing. There are countless substances that kill cancer but also kill the host.
Newer approaches look to the processes of cancer and how to deliver substances to the cancer cells using techniques similar to mRNA COVID vaccines.
They also look as to why when a substance is able to be delivered to the cancer why it is or isn't effective.
The area I see of great promise is directly changing the genes within the cancer to kill the cancer.
This is by deleting, modifying, or adding new genes elements. This is being performed on both DNA strands, and on just of of the strands. The methods to perform this editing are being discovered every week, if not days, or hours. It happening at breakneck speed and the accuracy and prevention of inaccurate changes improves constantly.
This gene editing can correct genetic defects to prevent or kill cancer caused by genetic defects.
I believe one of the many many versions of gene editing developed over the last few years or within the short future by various methods will provide the breakthroughs we are hoping for.
Keep yourself informed about these discoveries as trials using methods of gene therapy such as CRISPR likely will bring those breakthroughs.
Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.
Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.
The hits just keep on coming. 
Trying to come to grips with ADT 
Paul is coming home today
What the group is coming to
