biontech.de/ ... it is likely going to be what cures cancer in the next 5 to 10 years ... they have already done studies on over 200 cancer patients world wide .. with astonishing success.
I watched a live seminar hosted by Cancer Research Institute last week with the 4 Nobel Prize winners who developed mRNA and Dr. Allison with M D Anderson Cancer .. who have trials starting soon. I have attended 3 prior Cancer Research Institute events in Houston .. they are the leading force for immuno therapy for cancer treatment … they were behind Dr. Allison M D Anderson and Houston Methodist world leaders in immuno therapy research … check point inhibitors – Ipilimumab (Yervoy) Keytruda etc. before anyone in medicine thought the immune system could kill cancer.
The first year award in 1975 was shared by 16 scientists considered to be the "founders of cancer immunology." Since then, more than 85 scientists around the world have received it.
2021
Katalin Karikó, Ph.D.
Drew Weissman, M.D., Ph.D.
Uğur Şahin, M.D.
Özlem Türeci, M.D.
The 2021 William B. Coley Award for Distinguished Research in Basic Immunology was shared by Drs. Katalin Karikó, Drew Weissman, Uğur Şahin, and Özlem Türeci for their pivotal roles in the research and development that have led to novel mRNA-based therapeutic approaches that are currently being used to fight cancer and infectious diseases, including two of the most effective vaccines against the SARS-CoV-2 coronavirus that causes COVID-19. These technologies have the potential to redefine how we treat a variety of diseases, and are currently being investigated in influenza, HIV, malaria, sickle cell anemia, multiple sclerosis, and heart disease
“Join CRI for an in-depth look into the newest and most exciting approach to vaccination in our lifetime… mRNA vaccines. “
biontech.de/ has been developing mRNA for cancer cure for nearly 20 years -- it isn't all that new -- it just has been proven to be overwhelmingly effective and jettisoned forward by the Covid -19 pandemic ... maybe a blessing in disguise for cancer treatments.
Is this vaccine to prevent or treat. I’m headed to md Anderson first of dec and I’ll get a chance to ask my MO about it. He hasn’t called to let me know yet if I’m one the trial would be interested in.
It is to treat prostate cancer / it shrinks tumors by itself -- they said they give shot every 3 months to keep the killing of cancer cells up to eradicate the cancer entirely. They do it for one year and see what is left. The new trials are combining lite doses of Yervoy or Keytruda (checkpoint inhibitors) that release the immune system to help go after the designated snipit of code found only in the cancer cells ... they can and will soon make a version that is unique to the individuals own cancer... making it certain to kill the targeted cancer cells .... their current version -- is an off the shelf version that kills Pca cancer cells with code that all Pca cells have. They said they made 8 versions of Covid -19 within 24 hours of receiving the genetic code for covid.
So you can see -- when they get your biopsy tissue they can make a vaccine within 45 days.
Back in 2015 got a single injection of Keytruda + Yervoy + Opdivo in situ the Gleason10 tumor that 7 months earlier was cryoablated after a bilateral orchiectomy and then 1 month after injection began Cypionate biweekly injections with "T" level now hitting 1,600+/- ng/dL following injections. Still around with good and bad days like a 32 mile bicycle ride today after 63 miles on Saturday and trying for maybe 50 miles tomorrow. Axumin a couple of weeks ago showed all clear. Gonna "stay the course" until???
Just whining about this 71 year old body with 1 joint replaced and others that should have been replaced years ago and my choice to not take pain meds UNLESS severe so always in a *hurtin'4'certain* state from the other bone on bone joints and then there's the bicycle crashes that still happen embarrassingly due to being fortunate enough with a treatment protocol allowing activity like a bicycle ride on July 4th where at mile 100 of 102 miles I went down hard and impacted my left shoulder resulting in a minor rotator cuff tear that constantly reminds me at how stupid I was for going down. I often read or hear that being alive and in pain "is still better than the alternative" but when I think about that I ??? Wouldn't either the "alternative" be to be in paradise or nothing, and wouldn't either be better than this crap. Just my 3 cents due to inflation.
Based on the positive results so far, is it still five years away from being generally available to the stage 4 prostate cancer patients? It is difficult to get into clinical trials so it seems like it should be available as an option sooner than five years.
I was speculating about this with my wife last weekend. I told her that perhaps covid is the best thing that ever happened for people with prostate cancer.
Whatever you think of the chances, it is important to have hope. It keeps me active in my care.
Thanks George. Yep this has been brought up with a couple posts the last few days. Looks like there was some "truth" to the reports during the vaccine development that it would also be beneficial in accelerating use for cancer.
As someone else said though we can only hope. It's pretty much out of our hands. I do hope for a break thru for improved outcomes.
Anyway I have to stay lucky and survive long enough to see this come thru.
As CAMPSOUPS says, I have to live that long..... I plan to, I'm, only 4 years into the 10 yr plan I set up after a couple of repair surgeries.... Life Is Good, hope I'm around for a long while yet.
I posted this below but copied it here in case others have the same question.
It is to treat prostate cancer / it shrinks tumors by itself -- they said they give shot every 3 months to keep the killing of cancer cells up to eradicate the cancer entirely. They do it for one year and see what is left. The new trials are combining lite doses of Yervoy or Keytruda (checkpoint inhibitors) that release the immune system to help go after the designated snipit of code found only in the cancer cells ... they can and will soon make a version that is unique to the individuals own cancer... making it certain to kill the targeted cancer cells .... their current version -- is an off the shelf version that kills Pca cancer cells with code that all Pca cells have. They said they made 8 versions of Covid -19 within 24 hours of receiving the genetic code for covid.
So you can see -- when they get your biopsy tissue they can make a vaccine within 45 days.
In some cancers with checkpoint inhibitors alone they have a 60% to 70% plus virtual cure / control rate ... they have been combining Yervoy or Keytruda with low chemo or low dose radiation to trigger the immuine system to see the cancer as the radiation damages it and alerts the immuno system to the bad guys.. Jimmy Carter was cured of brain cancer with Keytruda alone ... skin cancer and lung cancer is very receptive to Keytruda alone... now that they have the genetic code to direct the immune system to the cancer and tell it to kill all cells containing the code -- messenger RNA -- it is highly likely it will at the very least control it if not eradicate it. They are already testing it in all types of cancer and diseases.
mRNA treatment could become a silver lining for all sorts of maladies. But it is hope that keeps moving us forward. Science is like the gift of fire to early man. We can worship it, demonize it, or use it as the tool it really is. Life by its nature is a finite gift of memories and it seems unfair for disease to consume so many of them. Still it is the hope that keeps us heading toward the light.
My PC spread to a muscle in my pelvic right side in June, causing extreme pain and wasn't able to stand. Also closed up my urethrae, so I was self cathing all day/night. Began Keytruda every 3 weeks along wth 24 consecutive proton beam radiation treatments. By the end of the treatments, i was pissing freely and standing without pain.
Just had full scans done ( bone and pelvic MR ) and met with MO to go over: "substantial decrease in tumor involvement", "undetectable".
Fantastic news Dave. Will you stay on Keytruda for a full two years? If so, will you just be monitored (PSA) or will you be given another drug? It might be a little early to get answers to these questions, so enjoy the "euphoria" that I also experienced.
Hey Tennis - Plan is to stay the course with Keytruda / 6 weeks with Lupron for 2022. My psa was never over 1.2 - just a non reporting form of cancer. Thanks for the positive words and congrats to your continued good health!
There is a phase 1 trial called pro-merit using mRNA vaccine from BioNTech. Does anyone know any results from this? Has anyone participated? I think it is ongoing and still open, listed in clinical trials.gov.
Yes I think this jumped out immediately for many of us upon first hearing about CRISPR and mRNA back in early 2000.
Covid-19 brought together many unvalidated aspects used in the production of the vaccine. I believe it was in the order of eight new technologies brought together.
This success opened the eyes of the world to these areas of research needed to produce it.
Now researchers and companies around the world are racing to enter this field of research. Looking for similar outcomes with a wide array of maladies affecting mankind.
Money is flowing to these efforts, where fortunes beyond any we know today will be made with these discoveries.
New discoveries are leap frogging the ones made a week before, and then being leapfrogged again.
I've mentioned this was the area I expected to produce real results for cancer and PC cancer at several appointments with my PC doctors assistants over the past two years and surprisingly they hadn't heard of it or knew nothing about it.
I do believe the treatments we have all been waiting for will rise from these new technologies.
The issue for us is when will these somethings be available and when will insurance pay for them and will be still around to take advantage of them.
I have read it has taken around 16 years on average for a discovery to become a FDA approved drug in the US. This delay is unacceptable for potential life saving cancer treatments.
But remember there are over 100 different cancers some say 200 depending on how you define different cancers. All need to be run through many trials to be found effective.
So many of us in the US may need to travel to other places in the world to pay cash if we can afford treatment.
I fully believe that for a 30 year old man in the developed world Advanced Prostate Cancer by the time he reaches his 50s and 60s will no longer be a death sentence it is today.
So for us the PC patients of today we need to influence the powers that be to RUSH clinical trials, get many many more trials in place.
And since trials usually start with the sickest of us, we need to get parallel trials going at all stages of the disease. With approvals for treatment at all levels of the disease if found effective at one level. We can't wait for serial trials one beginning after the other ends.
Governments must fast track approval and will need to decree that insurance companies MUST approve and pay for these treatments immediately from the time of doctor perscription.
Agree completely the serial trial approach makes no sense. It’s like there is no recognition that the majority of current treatments at all stages of prostate cancer have serious impact on quality of life. If men at all stages are willing to go on clinical trials to try out treatments that may improve quality of life from first diagnosis I can’t see why we stick with serial trials starting with the most sick. The current treatments need replacing urgently.
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What does the cancer in your back feel like? 
Thoughts on \"What it's like to die from prostate cancer\"
Looks like I've moved into castrate resistance territory. What next?
Immunotherapy (general) - Interesting NY Times Article.
