NKX3.1 found in liver biopsy

[Muffin2019]

The nkx3.1 was found in a recent liver biopsy. What does it tell the oncologist and what treatment would shrink the tumor ? Never heard of it and when looking it up it is confusing as it is in all prostate tumors from what I have read. They indicate it is a biomarker but how do you get rid of the tumor containing it ? Been on ADT with eligard for 5 years , most recent was cab that failed after 6 months .

[Tall_Allen]

It just confirms that the tumors in the liver are prostate cancer, and not some other kind of cancer. It has no therapeutic implications other than that the liver metastases may respond to the kinds of therapies that all prostate cancer may respond to.

[Muffin2019 in reply to Tall_Allen]

It does not indicate wether it is slow growing or aggressive and if it is PSMA emitting, correct ?

[Tall_Allen in reply to Muffin2019]

Nothing like that. It just confirms that it is prostate cancer. Doesn't your MO tell you this?

[Muffin2019 in reply to Tall_Allen]

I am seeing him next week, just si I know what it is. Not sure the direction and still waiting on MSK to get back with the first appointment. He referred them to me for treatment and clinical trials with plivicto. Going to mention a pet scan or maybe MSK will check that .

[Tall_Allen in reply to Muffin2019]

Yes, they have to do a PSMA PET scan before pluvicto. I think they should also do FDG, especially with liver metastases.

[billd50 in reply to Tall_Allen]

Curious about the FDG PET scan. What's the reasoning for it? Thanks.

[Tall_Allen in reply to billd50]

Read this:

prostatecancer.news/2019/12...

[Muffin2019 in reply to Tall_Allen]

Thanks, printed out to read later.

[Ingress in reply to Muffin2019]

who are you seeing at MSK?

[Muffin2019 in reply to Ingress]

Have not had my appointment yet.

[Mw921000000]

my dad had a bone biopsy from a fracture and it came back from pathology as consistent with prostate cancer, or NKX3. Which meant it wasn’t some other kind of disease or other type of cancer. So it just means the spots from your liver are metastases of your prostate cancer and can be treated using similar therapies

[Muffin2019 in reply to Mw921000000]

Thank you and I wish your dad well.

[j-o-h-n]

And of course we wish you well....... MSK is a great hospital....

j-o-h-n <===<<< Senior management is about to spike my spikes....

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 04/07/2023 2:22 PM DST

[Muffin2019 in reply to j-o-h-n]

Just waiting for first appointment, going to ask my oncologist next Tuesday with more questions. Always like your posts , take care.