I assume he already had a bone scan/CT and a PSMA PET/CT when he was diagnosed because of his high-risk diagnosis (PSA≥20). If so, he can wait for biochemical recurrence according to the SPPORT trial.
Thanks TA. With mention of neuroendocrine change in pathology, is there anything we should do differently? We're concerned of possible undetected progression.
High levels of Serum LDH, CEA and Chromogranin A may indicate progression to neuroendocrine. Also, there's been quite a few informative posts about it, such as this one by LearnAll...
to answer your question directly it is possible for neuroendocrine cancer to grow and not raise his psa. My husband’s psa was undetectable for this past year due to his current drug regimen and in the last month discovered a large mass in his groin when he started having urinary issues. We are in the process of dealing with treatment plans to reduce this tumor.
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