Help with deciphering

[Blue-Mockingbird]

I was looking over my husband’s VA medical information and need help understanding.

He recently had a liquid biopsy and the results state that he has “ATM mutation, VAF 68% which makes it unlikely to be CHIP”

Does someone know what VAF or CHIP is?

[Atdabeach]

Per a semi-deep Google dive, I get "Variant allele frequency" and "clonal hematopoiesis of indeterminate potential." Both might make sense in context, but I'm just guessing. Good luck!

[Blue-Mockingbird in reply to Atdabeach]

Thanks Atdabeach, that must have been a very deep dive 😉

[tango65]

ATM mutation has to do with the system to repair the cell DNA. The cancer may be susceptible to treatment with PARP inhibitors such as Olaparib or rucaparib or the combination of these drugs with abiraterone according to the Propel study.

The VAF 68% most probable indicates that the mutation in ATM is a germline mutation.

[Blue-Mockingbird in reply to tango65]

Thank you, Tango! I’ll be sure to ask about the Olaparib or combo when we next see his MO. She took him off the Abiratarone in early December in prep for possible BAT trial but that didn’t work out. He recently started Cabazitaxal infusions but she hasn’t indicated his need to return to any ADT drugs which concerns me

[tango65 in reply to Blue-Mockingbird]

Best of luck!