Zoladex

[Poowater]

I have resistant metastatic prostate cancer. In spine and ribs.I have been on Zoladex for just over 2 years. Now on Pluvicto as I have exhausted most treatments. As Zoladex has not worked I'm thinking about stopping it. Any advice?

[tango65]

It will make things worse. CRPC has much more receptors for testosterone than CSPC.

[Poowater in reply to tango65]

Many thanks. I would be interested to hear about studies supporting your advice.

[tango65 in reply to Poowater]

ncbi.nlm.nih.gov/pmc/articl...

[Poowater in reply to tango65]

Many thanks.

[tango65 in reply to Poowater]

Best of luck!

[Poowater in reply to tango65]

We all need some luck in our journey.

[tango65 in reply to Poowater]

Yes, we do.

[Tall_Allen]

You never stop Zoladex. It always works - reducing your testosterone. Your cancer and pain will get much worse if you stop.

[Poowater in reply to Tall_Allen]

Are there any studies that support continued use of Zoladex when castrate resistant? Why not intermittent use ? I note my FDG scan showed that I have only PSMA avid cancer, hence Pluvicto.

[Tall_Allen in reply to Poowater]

EVERY study of castration-resistant PCa uses Zoladex (or similar). Intermittent is NEVER used for castration-resistant men. One of the changes that occur in castration resistance is the amplification of androgen receptors - it makes your PCa much more sensitive to even the slightest amount of testosterone.

[Poowater in reply to Tall_Allen]

Many thanks for this advice. I have decided to stay on Zoladex.

[Stoneartist]

The way I see it you have both; CSPc and CRPc - the Pc doesnt a suddenly become resistant - the resistant tumours are a new mutation that has jumped out of the box. So your Zoladex is continuing to do a good job on the CSPc whilst the CRPc is developing. (Dont kow if this is science supported but it seems likely to me!!)

[Poowater in reply to Stoneartist]

Thanks so much. Often, logical explanations don't fit the science.

[Poowater in reply to Stoneartist]

Well put.

[Stoneartist]

Quite so - but good science is guided by logical observations - and starts as an hypothesis which then has to be proved - or disproved!!