Zoladex: I have resistant metastatic... - Advanced Prostate...

Advanced Prostate Cancer

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Zoladex

Poowater profile image
15 Replies

I have resistant metastatic prostate cancer. In spine and ribs.I have been on Zoladex for just over 2 years. Now on Pluvicto as I have exhausted most treatments. As Zoladex has not worked I'm thinking about stopping it. Any advice?

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Poowater profile image
Poowater
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15 Replies
tango65 profile image
tango65

It will make things worse. CRPC has much more receptors for testosterone than CSPC.

Poowater profile image
Poowater in reply to tango65

Many thanks. I would be interested to hear about studies supporting your advice.

tango65 profile image
tango65 in reply to Poowater

ncbi.nlm.nih.gov/pmc/articl...

Poowater profile image
Poowater in reply to tango65

Many thanks.

tango65 profile image
tango65 in reply to Poowater

Best of luck!

Poowater profile image
Poowater in reply to tango65

We all need some luck in our journey.

tango65 profile image
tango65 in reply to Poowater

Yes, we do.

Tall_Allen profile image
Tall_Allen

You never stop Zoladex. It always works - reducing your testosterone. Your cancer and pain will get much worse if you stop.

Poowater profile image
Poowater in reply to Tall_Allen

Are there any studies that support continued use of Zoladex when castrate resistant? Why not intermittent use ? I note my FDG scan showed that I have only PSMA avid cancer, hence Pluvicto.

Tall_Allen profile image
Tall_Allen in reply to Poowater

EVERY study of castration-resistant PCa uses Zoladex (or similar). Intermittent is NEVER used for castration-resistant men. One of the changes that occur in castration resistance is the amplification of androgen receptors - it makes your PCa much more sensitive to even the slightest amount of testosterone.

Poowater profile image
Poowater in reply to Tall_Allen

Many thanks for this advice. I have decided to stay on Zoladex.

Stoneartist profile image
Stoneartist

The way I see it you have both; CSPc and CRPc - the Pc doesnt a suddenly become resistant - the resistant tumours are a new mutation that has jumped out of the box. So your Zoladex is continuing to do a good job on the CSPc whilst the CRPc is developing. (Dont kow if this is science supported but it seems likely to me!!)

Poowater profile image
Poowater in reply to Stoneartist

Thanks so much. Often, logical explanations don't fit the science.

Poowater profile image
Poowater in reply to Stoneartist

Well put.

Stoneartist profile image
Stoneartist

Quite so - but good science is guided by logical observations - and starts as an hypothesis which then has to be proved - or disproved!!

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