PSA test vs ultra sensitive PSA test

[fourputt]

When PSA rises above .1 are PSA and Ultra sensitive PSA tests equally accurate ?

[LowT]

I had both done recently on same specimen and same lab.

uPSA 0.113

PSA <0.1

Must be some over lap in that range.

[LowT]

uPSA should be more accurate at such low level.

[Justfor_]

The inherent accuracy of the test itself is of secondary importance compared to the rounding error of the reported trancated value. For example if the accuracy of the test is +/- 10% a PSA of 0.15 can be measured by the analyser somewhere between 0.135 and 0.165. Reporting this with a single decimal place number will be 0.1 or 0.2. In such a case the rounding error is 3+ times that of the analyser. The two errors will become equal, resulting in a combined statistical error of +/- 14% or less at the value of 0.5. There is a hospital in the US reporting anything bellow 0.05 or 0.06 as undetectable. They don't lack accurate analysers. They know the basics of measurements.

[Tall_Allen]

Close enough. Post-SRT there is no longer any reason to use a uPSA test. The fluctuations cause anxiety without adding any decision-making information.

[fourputt]

Thank all of you very much, I really appreciate it.

[TJGuy]

The old fashioned PSA test to <0.1 performs rounding to stay at one decimal to the right of the decimal point. It can jump to 0.2 before it really is 0.2 due to rounding, and sensitivity of the test itself. These cost less.

These are used by some hospitals because they cost less, they don't begin therapy below 0.1. And they can tell you your undetectable or NED, for longer periods of time.

The newer more sensitive PSA tests have many different levels before the < sign becomes involved depending where you get your test performed. These cost more.

If your tracking to see if you have recurance, you can see that much earlier with the ultra sensitive tests.

If you just had a RP and really want to know your chances of recurance you can tell that by if your PSA reaches 0.02 or below without any ADT. If so you're unlikely to have recurrence, above that your odds are you're likely to have recurrence.

If your looking for your NADAR and you get a <0.1. Then it's time to get an ultrasensitive test.

Labcorp currently reports to <0.006 on either of it's ultrasensitive tests.

So following your level of PSA and the test you purchase makes sense. If your PSA is low use Ultrasensitive, if it's up above 1.0 you probably can get away without the extra senitivity. Certainly if your 10.0 there is no need for ultrasensitive until you become <0.1

[RMontana in reply to TJGuy]

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[RMontana]

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[RMontana]

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