Another piece of hope for us all?
bcm.edu/news/a-novel-strate...
Yang and his colleagues studied signals tumor cells use to drive cell proliferation. They knew that androgen receptor activation remained a key driver of the growth of castration-resistant tumors, so they focused on GATA2, a factor known to promote androgen receptor expression and activation.
“While directly inhibiting GATA2 activity remains challenging, enhancing GATA2 degradation to prevent androgen receptor activation seemed a plausible therapeutic strategy,” Yang said. “We discovered that the enzyme COP1 drives GATA2 degradation, and that this was followed by striking inhibition of androgen receptor expression and activation.
