A novel strategy to suppress prostate cancer growth

[Benkaymel]

Another piece of hope for us all?

bcm.edu/news/a-novel-strate...

Yang and his colleagues studied signals tumor cells use to drive cell proliferation. They knew that androgen receptor activation remained a key driver of the growth of castration-resistant tumors, so they focused on GATA2, a factor known to promote androgen receptor expression and activation.

“While directly inhibiting GATA2 activity remains challenging, enhancing GATA2 degradation to prevent androgen receptor activation seemed a plausible therapeutic strategy,” Yang said. “We discovered that the enzyme COP1 drives GATA2 degradation, and that this was followed by striking inhibition of androgen receptor expression and activation.

[Heykm01]

thanks for this post. Will be good to see some actual drug development news from this reasearch

[GSDF]

This is truly awesome hope! Thanks for sharing.

[Scout4answers]

As I keep saying... a cure or durable remission is most likely to come from an obscure, novel source,

[rococo]

they’re on the right tract attacking the last stage, the Androgen receptors of CRPC when adv pc begins its journey to full bloom MCRPC