Study finds intake of MK7 form of vitamin K2 does not impact vitamin K-dependent coagulation-"might help prevent bone & vascular diseases.”

[GeorgeGlass]

lifeextension.com/newslette...

One of the functions of vitamin K in the body is to maintain a healthy amount of blood clotting to protect against excessive bleeding. Based on this knowledge, drugs have been developed that antagonize vitamin K to help reduce blood clot formation (thrombosis) in individuals with certain health conditions. A concern has been voiced that adding vitamin K to the diet could contribute to an imbalance in the activities of blood clotting factors, leading to a greater amount of coagulation than is desirable. However, a study reported in the June 11, 2021 issue of the journal Medicine (Baltimore) has revealed that intake of menaquinone-7 (MK-7), a form of vitamin K2, was not associated with this effect.*

“As MK-7 is widely used by healthy and normal population for preventing osteoporosis and cardiovascular disease, physicians’ have raised their concerns on whether MK-7 administration can alter the hemostatic balance by inducing a thrombotic tendency in healthy populations,” Ruijun Ren of the Affiliated Hospital of Southwest Jiaotong University in China and colleagues wrote. “Although no increment of thrombotic events has been reported among vitamin K users, and long-term safety has been proved by many studies, few data are available with regard to the influence of vitamin K on activation of vitamin K dependent coagulation factors in healthy populations.”

The study included 18 men and 22 women between the ages of 25 and 40 years who received 90 micrograms of MK-7 daily for 30 days. Blood samples collected at the beginning of the trial and on days 7 and 30 were analyzed for routine coagulation parameters, including the clotting measurements of activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT), and plasma activity of vitamin K dependent coagulation factors II, VII, IX and X. Levels of uncarboxylated prothrombin (carboxylation of proteins by vitamin K is known to play a role in its health effects in other tissues) were also assessed at the beginning and end of the study.

Routine coagulation tests performed at the beginning of the study were within normal ranges and were not significantly different on the 7th and 30th days after beginning MK-7 intake. Similarly, coagulation factors II, VII, IX and X, and levels of uncarboxylated prothrombin were not significantly different at the end of the study in comparison with pre-intake values.

“The dietary intake of vitamin K is believed to be sufficient to ensure the activation of coagulation factors, and the present study is the first to reveal that additional MK-7 administration showed no overactivation of each factor,” the authors announced. “Our study might provide evidence in eliminating the concerns of hemostatic balance for MK-7 intake in healthy individuals to prevent bone and vascular diseases.”

*Ren RR et al. Medicine (Baltimore). 2021 Jun 11;100(23):e26221.

George

[cesces]

I couldn't find the actual study.

I am dubious about it. I wonder who funded it and why?

How many forms of k2 are there?

I am disappointed with lef.

They know how to do a proper DOI citation. It's not That hard.

[MateoBeach]

This should be taken as reassurance to those who take K-2 or MK-7. Keeps calcium going towards bone and not to arterial wall lesions, so seems a good idea for those who supplement with D-3 in Winter months or higher latitudes.

Only those who must carefully regulate Vitamin K to not interfere with a necessary anticoagulant therapy (Warfarin, Coumadin) must avoid supplemental K. For most others it is not a problem. Venous thromboembolic disease is a significant risk for those with cancer including APC. So prudent protective practices should be observed. No prolonged sitting without breaks. Compression stockings on long flights and drives.

And one could consider Nattokinase as a possible helpful supplement for additional protection. Previous discussions of this on this site .

[GeorgeGlass in reply to MateoBeach]

i agree. I have been taking the Natto for years. I eat it sometimes as well. I have been taking the mk4 animal tore off Natto supplements but now i just switched to the mk7. The mk 7 stays in your system longer as well, if my memory serves me.