Reducing docetaxel dose

[PHnerd]

Hi all, for his third chemo session the onc reduced his dosage by 25% because he was getting severe neuropathy in his left leg. Is this going to be less effective now?

[Tall_Allen]

Of course a lower dose is less effective. But the alternative is long lasting neuropathy.

[tango65]

If he has a severe neuropathy they should stop chemo and look for other treatments. Neuropathy with chemo could evolve from sensorial neuropathy to motor neuropathy with paralysis.

Consider to consult with a neurologist.

Neuropathies caused by chemo with taxanes may be permanent.

[rsgdmd]

I started getting peripheral neuropathy after my 3rd round. Not severe. Doc recommended Vitamin B6 100mg, three times a day. Never got much worse over next 3 rounds. Still take them along with alpha lipoic acid, 600 mg.

[MateoBeach]

Agree with Tango. If neuropathy develops on docetaxel it should not be used further even at lower dose. Discuss switching to Cabazitaxel.

[PHnerd in reply to MateoBeach]

He’s on a clinical trial so there’s no way to switch to a different chemotherapy without withdrawing from the trial.