Back on the sauce

[bigiron]

This is my first post, but I have been reading and learning for quite a while. Thank you to the Gurus on this site both past and present who have taught me. I can never pay you back what you are owed. May you all be blessed with a life full of days, and days full of life!

On to my story. After RP, HT, RT to pelvic area (not wprt see my profile for full history)

2/2/22 PSA/Testosterone results...PSA <0.02 Testosterone 376!

9/10/22 update. A lot has happened unfortunately.

5/6/22 t-628, PSA .34,, the beast is eating well! 5/31/22 PSA .29, 6/22/22 t-662 PSA .51, 7/25/22 PSA .55, 8/16/22 t-605 PSA .60...

Insurance approved PSMA Pyl test. Test on 8/17/22. Results numerous lymph node uptake on both sides of pelvic area and at Aortic bifurcation. Now node metastatic. Just when I was feeling so good! Numerous nodal uptake for such low PSA.

Firmagon shots on 8/19/22. Back on the sauce...

I am mulling over whether to go with abi +p or enz in combo with Orgovyx (pill lupron). Leaning toward abi +p. It seems RCT's for both show similar OS outcomes. Not interested in chemo yet but know it is around the corner. Any thoughts would be appreciated.

Thanks

Tim

[Tall_Allen]

Sadly, many men put off chemo until after it is too late to do much good and side effects are worse.

[monte1111]

Pizza, pizza, pizza. Chemo, chemo, chemo. As many cycles as you can stand. I did 8 cycles. ADT plus chemo plus zytiga or xtandi. Not a dr. of course. Trilateral not available 5 and a half years ago. I hang my head and cry.

[London441]

Fear not the chemo! Or should I say not advisable to be ‘not interested’ in it. As TA says, turn that corner sooner than later.

[Stevana]

I was diagnosed in 3/2020, Gleason 9, multiple Mets (advanced stage IV, hormone sensitive). Finished 6 rounds of chemo (Docetaxel) in early 12/2020 followed by switch from Firmagon to Orgovyx. PSA reached nadir in 03/2021 and has been undetectable since. All Mets are now stable. Recommend chemo as early as possible. Today’s chemo is not the same as earlier treatments. I mainly suffered fatigue, lost some weight and my hair (which grow back just as thick within a few months), but otherwise I faired quite well. I will likely do it again once I become castrate resistant. Hope this helps. Good luck.

[bigiron in reply to Stevana]

Thanks, I reviewed the RCT’s re chemo and triplet therapy and have decided to go with the triplet therapy. Thanks everyone for your guidance and advice. We all fight on.

[docbulldog]

I didn’t have chemo until it was apparently too late. My PSA continue to rise through 10 rounds of Docetaxel, I should’ve went to Chemo before I did Xtandi and Zytiga.

I am now using the LU 177 treatment, first round completed late August. But my PSA has continue to climb. It seems my neuropathy has gotten worse and have a little bit of pain in my hip area probably due to lymph nodes being affected. I’m hoping my oncologist will come up with a way to lower my PSA which is now in the 400 range.

i’ve had basically no pain through all the chemo infusions and prior treatments. I expected the pain to show up anytime, I can’t complain though as I’ve had many years of being pain free.