New study shows Impact of diet on PCa

[Scout4answers]

Fitness thru diet and exercise make a difference

youtu.be/-UBHmXVYz-k(Not working as expected?)

[cesces]

Yes. Exercise is a super drug.

[Purple-Bike]

A powerful statement for vegetarian foods, with PCa benefiting from animal fats. In particular, processed meats were singled out . I wonder where fat fish comes in, it's supposed to be very good healthwise. , It would have been interesting to hear if that is an exception to "animal fats being bad" in pca context.

[Soumen79 in reply to Purple-Bike]

Check the study report which is cited in this video

sciencedirect.com/science/a...

I think fatty fish is mentioned as a healthy lifestyle factor.

Please correct me if i am wrong.

Btw, i take home made tomato puree, any idea about ideal serving?

[Purple-Bike in reply to Soumen79]

Indeed, fatty fish is singled out as positive. At least one food that is both great tasting and healthy! Unfortunately I have no tips on serving of tomato pure, going down the rabbit hole may uncover something

[MateoBeach]

What does it really show? "Healthy Lifestyle" measure combined several components that did not separate out "diet" vs "exercise" vs "smoking", for example. Note also they conclude: "Adhering to a healthy lifestyle was not associated with a decreased risk of overall prostate cancer."

It certainly is a "feel-good" article about lethal PC risk. But can we conclude that the Healthy lifestyle as defined protected those diagnosed with PC from progressing to lethal forms? Would like to think so, but not enough here to make that conclusion.

No one here with APC is likely to drop our choices for healthy diet and exercise. (even though opinions vary widely) Rather we continue to strive to further improve and refine them. Thanks for posting, Scout.

pubmed.ncbi.nlm.nih.gov/356...

Abstract

Background: Prostate cancer is the most heritable cancer. There is a need to identify possible modifiable factors for men at an increased risk of prostate cancer due to genetic factors.

Objective: To examine whether men at an increased genetic risk of prostate cancer can offset their risk of disease or disease progression by adhering to a healthy lifestyle.

Design, setting, and participants: We prospectively followed 12 411 genotyped men in the Health Professionals Follow-up Study (1993-2019) and the Physicians' Health Study (1983-2010). Genetic risk of prostate cancer was quantified using a polygenic risk score (PRS). A healthy lifestyle was defined by healthy weight, vigorous physical activity, not smoking, and a healthy diet.

Outcome measurements and statistical analysis: Overall and lethal prostate cancer events (metastatic disease/prostate cancer-specific death) were analyzed using time-to-event analyses estimating hazard ratios (HRs) and lifetime risks.

Results and limitations: During 27 yr of follow-up, 3005 overall prostate cancer and 435 lethal prostate cancer events were observed. The PRS enabled risk stratification not only for overall prostate cancer, but also for lethal disease with a four-fold difference between men in the highest and lowest quartiles (HR, 4.32; 95% confidence interval [CI], 3.16-5.89). Among men in the highest PRS quartile, adhering to a healthy lifestyle was associated with a decreased rate of lethal prostate cancer (HR, 0.55; 95% CI, 0.36-0.86) compared with having an unhealthy lifestyle, translating to a lifetime risk of 1.6% (95% CI, 0.8-3.1%) among the healthy and 5.3% (95% CI, 3.6-7.8%) among the unhealthy. Adhering to a healthy lifestyle was not associated with a decreased risk of overall prostate cancer.

Conclusions: Our findings suggest that a genetic predisposition for prostate cancer is not deterministic for a poor cancer outcome. Maintaining a healthy lifestyle may provide a way to offset the genetic risk of lethal prostate cancer.

Patient summary: This study examined whether the genetic risk of prostate cancer can be attenuated by a healthy lifestyle including a healthy weight, regular exercise, not smoking, and a healthy diet. We observed that adherence to a healthy lifestyle reduced the risk of metastatic disease and prostate cancer death among men at the highest genetic risk. We conclude that men at a high genetic risk of prostate cancer may benefit from adhering to a healthy lifestyle.

[middlejoel]

No argument with the video, with the exception of weight bearing, I am right there. But... what's up with that yellow jacket? Ugg!