Salvestrol

[Teufelshunde]

I saw this post in Fight PC but no responses. I currently take Resveratrol, so I did some research and wonder if anyone here has any experience with this. The only downside I see in my searches is the doc that discovered this turned it into a supplement company. So if you are a doc that discovers something and can change a molecule, so it is a drug, it is ok, but not supplement. I understand difference in testing, etc but other than that, any thoughts on this.

Here is the post: Does anyone know anything about or have any experience of using Salvestrol capsules to treat PCa? A friend of mine told me about them and the claims that Salvestrol can kill cancer cells. There is quite a lot of positive information about them online.

[Tall_Allen]

There is also negative and neutral information. Beware of confirmation bias:

• From a mouse study:

"Based on these preliminary data that resveratrol may be harmful, caution should be advised in using resveratrol for patients until further studies can be conducted."

ncbi.nlm.nih.gov/pmc/articl...

• From an small RCT in men with BPH:

"However, prostate size and levels of PSA... remained unchanged."

onlinelibrary.wiley.com/doi...

• From a prospective cohort study:

"Resveratrol levels were not significantly associated with...cancer."

jamanetwork.com/journals/ja...

• From a small RCT:

"the active treatment group experienced a non-significant increase in the log-slope of PSA"

onlinelibrary.wiley.com/doi...

[Teufelshunde in reply to Tall_Allen]

Thanks for that. I made a mistake in my post. I did stop taking Resveratrol a while back due to studies like you showed. I do take Muscadine Plus and just refer to that as resveratrol type supplement but thinking of stopping that also.

[binati]

I saw in some articles that Resveratrol is good for PCa. However, when I learnt that peanuts contain Resveratrol I was sold. I love peanuts without salt of course. The rest as they say is upto the scientists to discover, prove or disprove. In general there is very little solid scientific evidence of any foodstuff, vitamins or supplements doing any good to men suffering for PCa. However, if you enjoy eating something or gulping it down do so at your own risk.

[j-o-h-n in reply to binati]

You know, you may have something there..... I never heard of an Elephant with Pca....(Can you imagine giving a full grown elephant a DRE).....

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 07/17/2022 10:23 PM DST

[Benkaymel]

I posted that original question about Salvestrol capsules in the Fight PC forum and am surprised that no one seems to have even heard of it, let alone tried it. It's been around for several years and has mostly positive reviews online although, of course, there are a few negative or sceptical ones too. I don't know if it will do any good, but with stage 4 metastatic PCa, I'm in the mode of trying anything that looks like it may give benefit.

[Herman_PSA_OK in reply to Benkaymel]

I'm in the same situation with you, stage-4. Here is my two-cents Benkaymel. Tried it for a few months with a initial PSA dip of 1.5 points one month later after starting taking Salvestrol. Afterwards my PSA slowly increased to wipe out the drop anyway. My humble opinion is don't waste your money. I just finished up the last of my pills, so I gave it a good try of wishful thinking. Nowhere the results of the detailed hype described in their ebook as well. Another learning experience.

[Benkaymel in reply to Herman_PSA_OK]

Thanks Herman, was you on any other treatment at the same time as taking the Salvestrol? Were you taking the recommended dose of 2 x Platinum per day?

[Herman_PSA_OK in reply to Benkaymel]

Hello Benkaymel, Eligard, Abiraterone & Dexamethasone 0.5 mg. at the same time. The recommended dose (points per capsule is there their unit of measurement) depends on your goal. I was taking two Salvestrol Platinum 2000 capsules (4,000 points) per day. Of course, the more points per capsule the more expensive. I did some serious searching and found a reasonable, but still expensive source. Heck, I even purchased their ebook on Kindle which really goes into their rationale and so call data research. By the way, they warn about not taking Salvestrol at the same time with Resveratrol within a three-hour window while taking Salvestrol.

As TA usually said, in so many words that certain supplements may artificially lower your PSA while not reflexing the true nature of your disease progression. You are better off concentrating your resources/efforts on diet, organic food and exercise to keep your body/immune system/mind in the best condition to slow things down and live another day in peace. God Bless! Herm

[Benkaymel in reply to Herman_PSA_OK]

Thanks again Herman, I bought the ebook too and am taking 2 x Platinum per day. I read somewhere that for serious illness recovery (i.e Stage 4 PCa), it's suggested that you should take 3 x Platinum which as you say, is even more expensive. I agree totally about the good diet of organic food and exercise which I'm also doing. As I've only just been diagnosed with my PCa, I'm only on ADT (Prostap 3) at present which is the standard first treatment by the UK NHS.

[MrG68 in reply to Herman_PSA_OK]

Certain supplements may interfere with the PSA test and give you a reading that is lower by some percentage. IMO, this is only an issue if you are looking at a specific singular absolute value in time. A better approach is to monitor your time series of PSA values.

The effects of the PSA test are not cumulative wrt to supplements. So if you had a PSA of 11 and it got measured as 10 with the supplement, the PSA will not compound - or show growth - as long as your supplement dosage stays the same. So the 10 should remain at 10 - even though it is technically artifically low.

If you draw a regression line with a time series of PSA value in Excel for example, you will get a trend line. You are looking at the gradient of the line for its growth. The supplement would move the whole line up or down because the effects are baked into each reading. This will not affect the gradient.

If the test did actually vary in a cumulative manner due to that supplement, the test is effectively rubbish becasue it's measuring capability is volatile and you can't rely on it.

Just my opinion.

[Benkaymel]

Thanks, that doesn't surprise me. I don't think any controlled trials have been done for it so there are only anecdotal stories to go on by people who've taken it.

[Benkaymel]

Thanks, I'm not taking any of those other products but will bare that in mind.