Modified Citrus Pectin Treatment in Non-Metastatic Biochemically Relapsed Prostate Cancer: Results of a Phase II Study

[Bigm789]

Modified Citrus Pectin

nutraceuticalbusinessreview...

mdpi.com/2072-6643/13/12/4295

[pjoshea13]

There was a thread on this last year. It had 54 replies, so might be of interest:

healthunlocked.com/advanced...

The author of the study (Eliaz) created the product 30 years ago. He is an author of 12 of the MCP studies.

econugenics.com/pages/dr-is...

His company, Econugenics, also makes ProstaCaid 6 caps twice daily for 10 days = $109.95.

Nothing very special in those caps, IMO. But maybe affluent members have had good results?

-Patrick

[Bigm789 in reply to pjoshea13]

Wrong 6 caps is 10 g which is ok to take in shake or with meals but you can get chewable citrus tangerine better pricing$.

EcoNugenics PectaSol

Modified Citrus Pectin for Total-Body Health & Optimal Aging - Daily Super-Nutrient for High Performing Cells - 120 Chewable Tablets

a.co/jfIOIAH

[pjoshea13 in reply to Bigm789]

I was referring to ProstaCaid.

[Shooter1]

After last CT scan with 4 new mets, I decided to add MCP to my diet. Added to herb tea in morning and cold tea later in the day. It is easy to get the 15 mg down. Hope it works. Had my #4 Xofigo infusion today and dr said it is my last acct results aren't what he was hoping for. MO ready to start zytiga and parp inhibitor to see if that will work since Xtandi is failing..wishing all of us luck with our treatments....

[lcfcpolo in reply to Shooter1]

Shooter. Wishing you all the luck, love and prayers that I can from England.Graham

[CAMPSOUPS in reply to Shooter1]

Not what we want to hear.Hope you are doin ok otherwise.

Keeping my hopes up that no matter what you throw at it next it works (even if it ends up being Zytiga).

You've had a second round of chemo therapy not more than a year ago if I remember right. Hopefully that was enough to re-sensitize your cells to next treatment.

[ucladany]

Please send me the link well. Thank you Nals

[Purple-Bike]

Trying to sum up from the previous thread on (modified) citrus pectin:

The 59 patient study on modified citrus pectin, MCP PectaSol, shows success, but as noted the sponsor is involved.

From the study referenced by Patrick: “Commercially available fractionated pectin powder (FPP) induced apoptosis (approximately 40-fold above non-treated cells) in both cell lines ... Conversely, citrus pectin (CP) and the pH-modified CP, PectaSol, had little or no apoptotic activity."

On a question whether there is any consensus on which product in the Market today is most similar to Thornes hypofractionated (FPP) Citrus Pectin, Patrick replied, six months ago, that he was not aware of such a product and “I think we are stuck with Eliaz & his high price MCP”.

From a study referenced by Patrick, it seems citrus pectin is not unique:

"However, biochemical analysis revealed that numerous commercially available and laboratory-produced modified citrus pectins fail to bind strongly to the family of galectins, making it unlikely that modified citrus pectins directly inhibit galectin activity in vivo .17 In vitro experiments demonstrated that citrus pectin fragmented by heat in a laboratory setting can induce apoptosis in human liver and lung carcinoma cells.18 4,5-dihydroxy-2-cyclopenten-1-one was identified as a cytotoxic molecule that mediated the effect; additionally, as an experimental control heat-modified galactouronic acid (the primary monosaccharide comprising pectin) also yielded this molecule and equally induced apoptosis.19 This suggests that the effect may not be unique to modified citrus pectin per se, but rather it may be conferred by heat treatment of any source of galactouronic acid. It is not yet known to what extent 4,5-dihydroxy-2-cyclopenten-1-one is cytotoxic to other cancer or noncancer cell types, and further it is unclear if commercial preparations of modified citrus pectin contain this molecule.

Until a credible mechanism of action is firmly established, and until clinical efficacy is more thoroughly demonstrated in additional trials, perhaps caution is warranted regarding the therapeutic utility of modified citrus pectin. However, due to its favorable effects on gastrointestinal and metabolic health, regular consumption of native pectin from citrus and other foods such as apples, pears, and plums should be encouraged for most individuals."

Patrick also referenced two studies on papaya pectin. Could this pectin be an improvement to MCP PectaSol, in the absence of the Thornes hypofractionated FPP Citrus Pectin which apparently would have been the best? It´s above my capacity to make a judgement on this!

researchgate.net/publicatio...

pubmed.ncbi.nlm.nih.gov/?te...

[Shooter1]

Yes, any info to help....Doug