Have any of you heard of this phase one trial? The drug is Inobrodib! I believe the case number is CSS1477. If any of you could help me in regards to this I would so appreciate it. It was offered to my husband. Hopefully we can get to Boston as often as they would like. It’s three times a week for a whole month and quite a few 12 hour days. Praying we can get a ride.
Clinical trial!!! : Have any of you... - Advanced Prostate...
Clinical trial!!!
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Fight11
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I wish you the very best with this trial - hopefully it will really turn things in a good direction. Take care of yourself too.
It's a drug that inhibits the "bromodomain" -a part of a prostate cancer oncogene (MYC). It is very active area of investigation:
ncbi.nlm.nih.gov/pmc/articl...
I’m not too familiar with reading into those clinical trials. Would you happen to know if they saw a good response?
They don't have results from clinical trials yet.
There was a paper last year that might interest fans of Johann de Bono.
"Targeting p300/CBP in lethal prostate cancer"
The drug in the study is CCS1477 (aka Inobrodib).
Full text: ncbi.nlm.nih.gov/pmc/articl...
-Patrick
To be honest I don’t understand how to read into those clinical trials. I feel like I have to be a doctor. Not sure if you know how to read into them maybe you could explain. Did they see a good response?
The exciting thing about the study IMO is the involvement of Johann de Bono, who has a great track record.:
I think it's worth talking to the principal investigator about their experience with the trial results so far. You will also get more information from the informed consent than is available from the clinical trials listing. When I spoke with Dr Dorff about the variety of trials she was able to describe the effectiveness of each treatment and which ones might best suit me.
Here's my simple language summary of the paper. CSS1477 blocks a different Androgen Receptor (AR) pathway than the one that is used by enzalutamide. There is a dose dependent response to the drug, with a patient given 25 mg tablet showing continued rise in PSA and a patient given 50 mg showing PSA dropping in half, then stabilizing.
CS 1477 also reactivates the pathway usef by enzalutamide, so part of the trial will look at combined CS1477 with either aberaterone or enzalutamide.
They found that the pathway that is fiwnrrgulated by CS1477 remains that way long after treatment us ended, which they believe will allow them to space out doses to reduce side effects.
It is good to see venture into this area as MYC Gene over expression is present in 12% of all PCa patients (approx.) to what I've have read (Cancer Connect), but an astoundingly high +75% of advanced and recurrent PCa patients.
I'm happy to see some attention being given to it. I've been interested since my first Gene test showed I have whole gene (MYC) mutation (over expression), but failed to really find any focused attention via drugs in an approved setting, or late stage trials. This is confounding due to its common existence among patients.
Good links above and an advanced thank you for the reading material as I dive in once again to absorb information in this area once again. Truth be told, it is very hard to keep up and try to follow all the possible paths in an individual setting (my own) as a result from genetic testing. All interesting of course, but the breadcrumbs rarely lead to conclusive results or even available treatment.
Best Regards
My husband entered that Phase I trial in August. The first cycle is a tough one with the 8 hour observation after the injection. We had 2 weeks of that and then 2 weeks off. One of those weeks were labs, the other scans. No other problems, just the long wait. After that first cycle, the observations were down to 4 hours. He had no large side effects, just a little fatigue for the next day. Unfortunately he was dropped from the study in November. He was making progress in dropping the PSA, but the drug company wanted a better and faster drop. At least that’s what we were told. You may want to ask about the company’s reimbursement for mileage and lodging. It was appreciated, especially the lodging, after those long days. We were an hour’s distance from the treatment facility. I hope for better results for your husband. My husband’s thought going in to this trial was if it helps him, fine. If not, it may help someone else. We have been waiting for his qualification for another trial. Our Dr practically danced into the room with the news of Lu 177 yesterday He has upcoming scans to determine his participation. Take care, remain positive, and all the best to you!
What was the drug he was on thank you
Thank you for sharing. Interesting about reimbursement and why they told you he was dropped.
Hopefully he gets into this trial and "cures" him. If I lived in your area I would have volunteered to drive you and your Husband (HIS FIRST NAME PLEASE) to Boston for his treatments.
Good Luck, Good Health and Good Humor.
j-o-h-n Friday 03/25/2022 7:26 PM DST - Greek Independence Day.
