Thanks to all for your response. As a follow up I am posting the results of my PSMA scans hoping I can get some direction for what is next.
1. Interval disease progression I the region of the left seminal vesicle with now a 4 cm area of soft tissue thickening and intense radiotracer uptake, extending to the base of the prostate and possibly into the perirectal space as described.
2. Several new areas of nodular perirectal involvement as well as a new right medial common iliac lymph node with intense activity.
3. No evidence of active disease outside of pelvis.
4. No evidence of increased bony activity with scattered sclerotic disease stable as before.
Thanks for your help in plotting my next move