PSA started at 250+ in November. Got down to 7 in April. Since then has risen to 19 in July. Had a bone and CT scan. Unfortunately it was mixed news. There is evidence of progression in my bone disease. However, spots on my lung and Kidney are gone. My Onc wants me to start on Xgeva in two weeks. He has also discussed next steps. First he has upped my predisone to 10 Mg. Not confident in that.
He then discussed three options. I'm reviewing them now and will make a decision with him next week.
First is change to Xtandi. On average he has seen this work for only a couple of months but has have a couple of his patients do well.
Second is chemo with either Taxtere or a platinum based drug. I'm Brac2 positive and he says there is evidence that Brac2 responds better to platinum drugs.
Finally is a clinical trial involving parb inhibitors. Waiting to see if I qualify and then I will get details.
Has anyone been involved in a clinical trial? Have you after only one treatment has been completed? Just curious what you have done?
Also anyone have experience with Xgeva?
Follow your pros . I’ve been on prolia which is a lesser dose of Xgeva I’m told. I’m on it for osteopenia from adt and Rt . Many guys have success with bone metzs on Xgeva... Good luck. You have other tools your belt. Keep rolling .. anything to slow APC’s roll on us . Good luck Newyork!🤙🏽
Make sure you have a dental checkup. Do not want to be having teeth removed while on Xgeva (Denosumab)