Orgovyx vs Lupron

[ck42]

Can anyone point me to studies comparing the two for cardiac effects ? After 3 years on Lupron/Zytiga with undetectable PSA and otherwise doing well, I've developed atrial fibrillation. My MO is not giving me much guidance on the subject so a switch is strictly up to the patient.

[spinosa]

Someone here - I believe - posted a study that identifies a correlation between atrial fib and PCa

[Tall_Allen]

I haven't seen a comparison on arrhythmias, which are a rare side effect of either. Arrhythmias occurred in 0.6% of men taking Orgovyx, and 3% of men taking Lupron had a prolongation of the Qtc>80ms. Afib is more commonly associated with Zytiga. Your atrial fib may have another cause. Recently, Covid-19 has been identified as having long-term effects on arrhythmias