The immune system and Prostate Cancer

[Javelin18]

During my consultation with Dr Aparicio, we talked about checkpoint inhibitors. She said the thinking about why prostate tumors are cold, is that Tumor Associated Macrophages loeer T cell infiltration. I decided to dig into this and came across a summary of the Tumor Immune Microenvironment. Here’s the article for anyone that’s interested in some light reading over the holidays.

ncbi.nlm.nih.gov/pmc/articl...

[Tall_Allen]

That's but one of the reasons.

[j-o-h-n]

I think I'll pass......Thanks anyway....

Good Luck, Good Health and Good Humor

j-o-h-n Wednesday 12/22/2021 7:02 PM EST

[BruceSF]

Thanks you for sharing your journey with us. You seem to have learned a great deal in a short amount of time, and it's very enlightening to get the perspective of someone who is pushing the envelope.

You might be interested to know that there's a study at UCSF (clinicaltrials.gov/ct2/show... in which Dr Rahul Aggarwal 'primes' the t-cells to be sensitized to the cancer with a single dose of Lu-177 so that subsequent treatments with Keytruda can remove the checkpoint barrier. I'm in a support group with someone in the trial, and he says that they have some success (unfortunately, prior taxane treatment is a disqualification for the actual trial). Perhaps Dr Dorff might be willing to try it off-label . I've heard that Merck is fairly open minded about supplying Keytruda to clinical investigators, so it might be worth a try.

Dr A presented a poster at ACSO last summer, I can try to PM you a copy if you're interested.

There's a similar trial in Australia (clinicaltrials.gov/ct2/show....

Also, have you considered BAT therapy?

Bruce SF