How diet and gut microbiome can affec... - Advanced Prostate...

Advanced Prostate Cancer

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How diet and gut microbiome can affect castration sensitive vs resistance

GeorgeGlass profile image
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GeorgeGlass
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LearnAll profile image
LearnAll

Doxycycline 100 mg a day is part of Care Protocol (Statin+Metformin+ Mebendazole +Doxycycliine) I wonder if Doxycycline stops growth of "problem bacteria" in the Gut and that in turn facilitates Good bacteria growth in Gut obtained by eating homemade Yogurt made with high quality probiotic capsules._

GeorgeGlass profile image
GeorgeGlass in reply to LearnAll

that's what I was thinking about Doxy, although I wonder if it damages any of the good bacteria. I can't take Doxy anymore because it will likely trigger a relapse from my floroquinolone acquired disability damage.

Are you taking Mebendazole? I don't recall looking into that?

How do you make your homemade yogurt? I avoid most dairy. Do you use dairy, or some other base?

I read an article today on butyrate and took this as the one item that was new knowledge to me:

"In the case of this study, the types of fructo-oligosaccharides (FOS) were foods like onion, asparagus and bananas, and the resistant starches (RS) that were used were whole grains & legumes. Whole grains and legumes are actually two food groups that I do not generally recommend that my clients eat since they can aggravate many gut disorders for reasons that we will not discuss in this post.

Another study (18) showed that supplementation with FOS found in specific kiwifruit resulted in a 100% increase in FP over a 4 week period. This is a major finding as there are numerous studies now reporting that a relative shortage of FP bacteria is linked with several major gut disorders – most notable the inflammatory bowel diseases Ulcerative Colitis & Crohn’s disease."

LearnAll profile image
LearnAll in reply to GeorgeGlass

Making Home made Yogurt: Its easy ! I get a liter of organic, grass fed Cows Milk from Amish people who sell it every morning to a nursery near our house.Boil the milk well and let it cool. Remove the cream as much as possible. Then, sprinkle two capsules of High quality probiotic contents in it. Stir well. Leave this container at room temp for 48 hours. Yogurt with huge amount of good bacteria is ready to eat. I eat this yogurt..one cup every morning with breakfast.

BTW, its the saturated fat in Dairy which is the problem but not the fat free part.

dhccpa profile image
dhccpa in reply to LearnAll

I've seen other posts contending that dairy protein is bad, and dairy fat OK, for PCa. Have you heard that viewpoint before? Maybe on another forum.

LearnAll profile image
LearnAll in reply to dhccpa

Whoever posted this just does not know. The most favorite food for Prostate Cancer is saturated fat in contrast to other cancers which utilize sugar.There have been some rumors about Milk protein Casein being bad for PCa. But very large epidemiological studies done recently concluded that milk does not cause increased risk of PCa growth. We just need to avoid Milk Fat...and use fat free or low fat Milk. BTW, Cheese has a lot of saturated fat..so cheese needs to be avoided.

The study was posted by Tall Allen about a year ago on this forum...His title is " Cow juice is OK." Note the huge sample size (almost 50,000 men) in this study.

"ncbi.nlm.nih.gov/pmc/articl...

dhccpa profile image
dhccpa in reply to LearnAll

I believe casein was the concern among those posters. As for saturated fat, is that for just early stage PCa, or applicable to metastatic as well? I do get small amounts from cacao butter, but I don't consume dairy.

LearnAll profile image
LearnAll in reply to dhccpa

all the way up until PCa reaches terminal stage, its saturated fat what it likes..Then, in terminal phase, it learns to use sugar and become more like other cancer.

in reply to LearnAll

What studies show this conclusively?I do not believe the research supports your claim that PCa uses only saturated fat early on.

CSHobie profile image
CSHobie in reply to

I love saturated fats, beef, cheese, yoghurt. I don't think PCa is so simple minded, but I have cut down my consumption of big BBQ meals.

in reply to CSHobie

Cutting down on Saturated fats is probably a wise choice for cardiac health but whether it controls PCa growth is not confirmed. As Gregg57 stated awhile back and I paraphrase here: I won't be regretting eating bbq on my death bed.

GeorgeGlass profile image
GeorgeGlass in reply to

Thats the beauty of choice Tom. We all get to choose how we treat the body. I find enjoyment in eating the plant based diet. I know how to season things in a healthy way to make it taste good. I think it slows the cancer but those that want to eat the other stuff are welcome. I wish I could cure everyone on this website so we wouldnt have to think about this stuff as much.

in reply to GeorgeGlass

Same here but a nice NY Strip, or BBQ Ribs now and then will not move the PCa needle.

GeorgeGlass profile image
GeorgeGlass in reply to

Who knows. If you love it, then have it, just go with grass fed pasture raised cows without antibiotics, and keep the portion sizes low. I never really liked steak much, so I never miss out on it.

LearnAll profile image
LearnAll in reply to

Tom X 2, Let me bore you with old and often repeated phrase..."What is good for Heart is good for prostate"

in reply to LearnAll

All well and good but you made the claim the pca uses saturated fat as if that is a proven fact. "all the way up until PCa reaches terminal stage, its saturated fat what it likes."

I don't believe that pca that to be the case based upon my readings of several studies and believe omega 6 is the worse than saturated fat.

LearnAll profile image
LearnAll in reply to

Please watch the video on youtube "does sugar feed prostate cancer" by Oncologist Mark Sholtz.

in reply to LearnAll

If life were that simplemedicalnewstoday.com/articl...

GeorgeGlass profile image
GeorgeGlass in reply to CSHobie

everyone's cancer is a little different. Some are more simple minded than others, and sometimes, simple actions have big results. Not for everyone, but for some. It's worth trying to do the healthy stuff and it might work for you.

cigafred profile image
cigafred in reply to LearnAll

If the fat-free part of dairy is ok, then what about non-fat kefir for the pro-biotics?

LearnAll profile image
LearnAll in reply to cigafred

Minimum saturated fat esp from animal sources is what should be the goal.If you want to know more titles "does sugar feed prostate cancer.." By Dr Mark Sholtz.

Its 1 year old video and is still there on You Tube.

GeorgeGlass profile image
GeorgeGlass in reply to LearnAll

This is what I subscribe to as well. I do eat avocado and almond butter and nuts but my triglycerides test results this week were 45! They were 255 when I used to eat pasta and chicken type garbage all the time. I had never gotten the triglycerides below 87 (last year) and then this week they are 45. I did it by reducing the hummus, avocados and nuts, and increasing the vegetables even more. I also eat a slice of onion before every meal.

GeorgeGlass profile image
GeorgeGlass in reply to cigafred

I sometimes buy wallaby unsweetened. It's pretty low in sat fat and in sugar

Purple-Bike profile image
Purple-Bike in reply to GeorgeGlass

GeorgeGlass, can you give the link to the study nr 18?

GeorgeGlass profile image
GeorgeGlass in reply to Purple-Bike

nr18? what's that? Can you open this: sciencedaily.com/releases/2...

Purple-Bike profile image
Purple-Bike in reply to GeorgeGlass

Yes, thanks. It´s prevotella stercorea that we want to have. Unfortunately, it appears not to exist in any supplement. We will have to wait for it to come.

ck722 profile image
ck722

I make my own sauerkraut. Easy to do and inexpensive. One needs to eat sauerkraut and or yogurt daily as some of the "good" bacterium they impart is "non-resident" and as such must be replaced daily. You can get addicted to kraut on toast with a soft egg.

spencoid2 profile image
spencoid2 in reply to ck722

yum, that sounds great. i made my own kraut several times but got out of the habit. it is real easy. i also made kim chi which is more of a challenge getting the spices right, when it is good it is good but when it is bad it is BAD last batch was difficult to eat and i threw out half of it. if you do make kim chi don't cheap out and use green cabbage, it needs to be nappa.

ck722 profile image
ck722 in reply to spencoid2

Caraway seeds really liven up the kraut.

spencoid2 profile image
spencoid2 in reply to ck722

cabbage is on the list, this could become my daily breakfast, much better than breakfast burritos other than the ones at the hospital. best i ever had, seriously. unfortunately the kitchen is closed non patients and staff due to covid. the restaurant is the best one in town but my kraut and egg sandwiches will be a treat and i am not willing to get hospitalized just to get a good breakfast.

GeorgeGlass profile image
GeorgeGlass in reply to ck722

How do you make it?

Jbooml profile image
Jbooml

Seems somewhat of a stretch as so many of our new era drugs block the AR? leaving any excess androgens ‘all dressed up but nowhere to go’

I do hope they’re on to something though. Nothing more bitterly disappointing to see our fellows struggling with CRPC.

Nice find George. You’re always on the lookout for a lateral solution….fits my reasoning.

GeorgeGlass profile image
GeorgeGlass in reply to Jbooml

I do a lot of searching. Google also knows what I want to read so they send me recommendations and I read through them. I read another one yesterday. I'll post that as well. Maybe guys will be interested in that as well. If it doesnt help with cancer, it will help with heart and other body parts.

I agree with you. It is so sad to see other guys getting sick and/or passing on :( I was hoping five years ago that more breakthroughs would have occurred by now. I met with my MO two days ago and he's still SoC focused in everyway. I'm just staying with him to have a link to his hospital in case I need something from them. I'm seeing four different doctors just in case I need something from them.

Jalbom49 profile image
Jalbom49

I have been making L. Reuters yogurt from before prostate cancer, using half and half and Starter from the Wheatbelly blog. Encourages oxytocin.More recent dietary research shows that saturated fat in the blood correlates better with increased carbohydrate consumption rather than saturated fat consumption.

So, paradoxically, a keto diet may be good for your heart and not bad for prostate cancer.

Also avoiding vegatable oils which are n-6 heavy lowers systemic inflammation.

GeorgeGlass profile image
GeorgeGlass in reply to Jalbom49

Interesting, I'm about to post an article I read yesterday about keto vs low-calorie diets. Good to hear what you said about saturated fats because I like nuts and almond butter, and avocado. My triglycerides test result two days ago was 45. I couldn't believe it. My Trig/HDL ratio changed from 3:1 7 months ago to 1:1 now. First time in my life I ever got below 2:1 ratio. My HDL result was 42. That's the highest I've ever tested on that.

Jbooml profile image
Jbooml in reply to GeorgeGlass

Spectacular George…my cholesterol is so bad I’ve literally given up on it….the one crazy number that bolsters my disresolve is hdl which stubbornly hangs around 1.7…that’s in Canadian numerology

GeorgeGlass profile image
GeorgeGlass in reply to Jbooml

I bet that if you made the same changes that I did, your numbers would probably improve a lot. I can tell you what I eat on a daily basis if you'd like.

Jbooml profile image
Jbooml in reply to GeorgeGlass

Ya…is welcome it.

Jbooml profile image
Jbooml in reply to Jbooml

I’d

jamfrak profile image
jamfrak

This is an exciting study. It's behind a paywall unfortunately. A key aspect of the study's findings is that it's important to precisely manage specific probiotic organisms in the gut. The key positive bacteria is Prevotella Stercorea, which appears to help prevent mPCa progression during ADT. A closely related bacteria – Prevotella Copri – encourages mPCa progression during ADT. Random ingestion of consumer probiotic products may do more harm than good. A plant-based protein high-fiber & carb diet, rather than a meat protein & fat diet, may encourage growth of Prevotella Stercorea, but this is not assured. I've searched high and low but can't find any probiotic supplement or beverage on the market containing Prevotella Stercorea. I've found some pharma suppliers that have it but they'll only sell it if it's for research purposes, NOT treatment. Anybody know of a consumer product that contains Prevotella Stercorea?

GeorgeGlass profile image
GeorgeGlass in reply to jamfrak

I search a lot too and came to similar conclusions. I eat the forksoverknives type diet, which you described. My lipid results were astonishing two days ago. I have found certain probiotics that seem to do amazing things in test results. One of them is culturelle. I also found some food items mentioned in a couple study result articles that seem to facilitate Prevotella Stercorea. One of the foods is kiwifruit. I eat mostly leafy green salads with veggies, some fruit, vinegars, horesradish, nuts etc, egg whites with mushrooms and onions. I eat a slice of onion before every meal, raw. I eat sprouted high quality oatmeal, More veggies, some whole grains...

jamfrak profile image
jamfrak in reply to GeorgeGlass

Can you point me to studies that mention foods that contain Prevotella Stercorea (PS)? I'm taking a prebiotic fiber powder. PS likes a high-fiber microbiome environment. FYI, I'm taking Garden of Life Organic Fiber powder each morning with corn flakes and soymilk.

jamfrak profile image
jamfrak in reply to GeorgeGlass

I just ordered a Viome Gut Intelligence Test. Costs $65.06. It will give me a precise list of all the active organisms in my stool sample, including Prevotella Stercorea or Prevotella Copri if they're present.

GeorgeGlass profile image
GeorgeGlass in reply to jamfrak

Great. Let me know your findings, if you don’t mind.

jamfrak profile image
jamfrak in reply to GeorgeGlass

Sure. Will share my results. The test results will indicate the presence of organisms but not their proportion of the total organism population, unfortunately. So I may have a huge population of Prevotella Stercorea and a tiny trace of Prevotella Copri but all i'll know is that both are present in my stool sample. What I want in future is a test that indicates organism presence AND population proportion. And of course a test that's cheap enough to do, say, monthly testing to ensure that my gut microbiome is what i want it to be.

ck722 profile image
ck722

epicurious.com/recipes/food...

I make mine in 1/2 gallon canning jar. Use a loose fitting lid to let the gasses out. I use the non gasketed plastic lids. Fill the jar 3/4 full then the rest of the way with water to 1/2" from the lid. Add a teaspoon of salt to the newly added water. I let mine ferment 2-3 weeks. Let it ferment to taste. It ferments faster in warm weather. In the winter I ferment it near the wood stove that is burning 24/7. I pound the cabbage for about 10 minutes. Nothing is critical, vary your process to suit your taste. Whilst fermenting place the jar in a dish as the active ferment usually burps out making a stinky mess. If a little fuzz grows at the top just scrape it off.

A little coconut oil spread on toast with kraut and a soft fried egg is a real treat. Cancer killer? Probably more a slower downer than a killer. Either way one of my little pleasures.

enjoy

GeorgeGlass profile image
GeorgeGlass in reply to ck722

Ok, thanks man. I appreciate it. I'll give it a try.

ck722 profile image
ck722 in reply to GeorgeGlass

Check out several recipes on the web

GeorgeGlass profile image
GeorgeGlass in reply to ck722

I dropped coconut oil due to damaging effects on coronary artery disease. Egg yolks promote cancer growth but i eat alot of egg whites.

babaxiong profile image
babaxiong

There is new research showing ADT actually affects the gut biome to grow PCa…..look into it. Another reason to reject chemical castration.

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