Results are in. Now what the heck do they mean.

[Costarica1961]

I received my foundation 1 tests, I attempted to decipher on my own, one is liquid and the other is solid tumor I believe. I understand the objective, this will provide my oncologist with targeted information to plan out my treatment ,now and in the future as well as direct me to possible clinical trials. My curiosity is which are the problematic mutations and what information is important for me to know to better understand my specific cancer. I am not sure what info is important for me to deciminate the test results. My onc appt is not until next month. Chomping at the bit. To know more.

[Dachshundlove]

Costarica1961

I’ve learned more about this subject than I’d ever cared to.

Post your mutations and I will

Give you that I know. We’ve done/ germline/ tumor and liquid biopsy testing.

My husband has a few unfortunate mutations.

[Costarica1961 in reply to Dachshundlove]

Hi can you give a example of a mutation code. Thankyou.

[Dachshundlove in reply to Dachshundlove]

(Gene) (Variant)

ATR L1944V

SMAD2 Q249P

PIK3C2 YI3855

Thr first letter/numerical combination is the gene the second is the variant of the gene (exactly what about the gene is unique in the individual). Some unique variants change the way the gene (which is a protein) function And are known as “pathogenic” mutations.

Some variants are of “unknown significance” because the data on them is conflicting or there is not enough data. In my opinion, it’s important to know if you have any of these if you are showing early treatment resistance.

My husband appears to have primary chemoresistance and it turns out he has a genetic variant of “unknown significance” Which is Likely pathogenic based on how he is responding to treatment.

Some variants are “benign” which means they look different but don’t change the function of the protein.

[Tall_Allen]

The Foundation One reports I've seen tell you which are the actionable mutations. Sadly, most of the time, none are actionable.

[Costarica1961 in reply to Tall_Allen]

Hi Allen, my bio marker MSI was undetermined

My Genomic findings for positive mutations

AR amplification

CDH1 REARRANGEMENT EXON9

TP53 Y163C

MY FOUNDATION ONE CDX NOTHING DETERMINED.

What does this mean ? What significance does it have on future treatments.

Thankyou Rik

[Tall_Allen in reply to Costarica1961]

Unfortunately, it has no implications for future treatment. AR amplification always occurs with castration resistance. CDH1 and TP53 are tumor suppressor genes whose function is usually lost as a cancer metastasizes.

[Dachshundlove in reply to Costarica1961]

Are there any codes listed (on foundation one report)

Under “variants of unknown significance”

And if so, please list them too.

I echo comments from TallAllen.

Your prostate cancer will keep changing, which means, if you repeat a liquid biopsy down the road, they may find actionable mutations that they did not observe this time around.

[Costarica1961 in reply to Dachshundlove]

Sorry it took so long to send I appreciate your insight. AS LISTED UNKNOWN VARIANTS

BRCA2. KDMSA. NBN. RAD54L.

THANKYOU

[Dachshundlove in reply to Costarica1961]

What exact variant of BRCA2? There should be numbers and letters below that. Our oncologist says that 50% of the BRCA2 variants of unknown significance respond to platinum chemo and parp inhibitors.

If you let me know the exact variant I’ll ask Monday when we see him. He is involved in genetic targeted therapy research in PC.

[kidclutch]

hello!

the foundation one results packet should have several pages including a list of suggested therapies, and potential clinical trials. PIK3 mutations are reasonably common in breast cancer, so there is a possibility of experimental drugs in addition to a list of FDA approved drugs and combos.