Some queries

[Knittingque]

l haven't been on this site to add anything for a while but still look at postings each week.

My husband has had a second 6 month ct scan plus bone scan after his psa rose from nadir to 27 in the past two years. Initial treatment was Adt ànd radiation to prostate bed psa then was 65. He is having no treatment other than out of the box stuff now. His Oncologist head of Research very well regarded at Vancouver BC Cancer Center and his Urologist both examined his scans, no metastases anywhere. Ct clear prostate normal size. Latest psa shows drop to 25. What l cannot understand is why the psa is still in this range when they cannot find anything. They just told him that it looks as though his own immune system is fighting it and to keep doing what he is doing, something is happening. l find this strange as he is immunocompromised as he has no spleen and one kidney due to a serious accident when he was 28. My husband is now 69, healthy, follows a strict diet and apart from the usual age related aches and pains. He has an oustanding unbelievably positive outlook he is amazing and he still works physically part time. l have searched incessantly trying to understand whats going on with this psa. If anyone can shed some light l would be appreciative.

[tango65]

You could discuss having a PSMA PET/CT (Ga 68 or 18 F DCFPyl) or an Axumin scan . These techniques have a higher detection rate than CT scan and bone scan.

[Knittingque in reply to tango65]

We have Pet scans here in BC but my husband was told it could take a long time to get one given he is on no cancer meds.

[tango65 in reply to Knittingque]

There are clinical trials in the USA for these tests:

clinicaltrials.gov/ct2/resu...

clinicaltrials.gov/ct2/resu...

There are also clinical trials in Canada:

clinicaltrials.gov/ct2/resu...

clinicaltrials.gov/ct2/resu...

Perhaps you consider to talk with the people running these trials to see if he qualifies.

[Knittingque in reply to tango65]

It never fails to astonish me on this site how many of you out there care and truly are amazing in your compassion and help, you truly are an army of soldiers looking out for one another. Blessings in all you are and thank you to the one's for responding to my questions so quickly.

[tango65 in reply to Knittingque]

Best of luck on this journey.!!

[Tall_Allen]

It sounds like prostatitis or urinary retention.

[Knittingque in reply to Tall_Allen]

He has no urinary issues and his prostate is normal in size so inflammation doesn't seem to be a problem

[Tall_Allen in reply to Knittingque]

Prostatitis often does not have urinary issues and does not enlarge the prostate. It also does not respond to antibiotics. The only "symptom" may be an elevated PSA.

[Knittingque in reply to Tall_Allen]

Thank you TA for your response it is something to investigate watch this space as the Brit's would say however left there eon's ago however gotta keep that sense of humour though no matter what lol😂

[monte1111 in reply to Knittingque]

Isn't TA amazing? If it is prostatitis, that has to be better than cancer. Wishing you the best.

[Knittingque in reply to monte1111]

Thank you and to you the best

[MateoBeach]

It is unlikely to be from prostatitis. He has prostate cancer confined to the prostate treated with radiation and 3 years ADT. So far no mets on scans, but biochemical recurrent indicated by rising PSA from a very low nadir to 24. Cancer is still in the prostate and/or micro metastatic. Not sure what could be done with the prostate. ??? HDR brachytherapy? Need experienced expert opinion on that, someone who does it. Would want a PSMA PET scan to look re closely for mets which would negate treating the prostate. Otherwise continue AS and deciding when to escalate with further systemic treatments. Good luck.

[Knittingque]

Thank you for your response be safe🤒😷