He has bone and Lymph node Mets (marrow involved) but not any visceral Mets and neither any of BRCA/HRR genes came +ve (As somatic BRCA/HRR test failed on old biopsy blocks).
Do u still feel, Adding Carboplatin would be more effective in our case?
The trial did look at certain biomarkers. BRCA/HRR did not make a difference. But they defined a type that they called "aggressive variant PC" that made a big difference on whether the cocktail was effective. The aggressive variant was positive for mutation or loss of at least 2 of the 3 tumor suppressors: TP53, RB1, and PTEN
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