Jevtana (cabazitaxel) treatment..

[Fairwind]

Have any of you recently undergone this rather aggressive chemotherapy and if so, how did it go ? How would you rate the side effects compared to other treatments you have tried ? Was the improvement in your condition worth enduring the side effects ?

[Dan59]

I did Jevtana 8 rounds in very late stage after 12 rounds of docetaxol. My hair grew back after docetaxol, and got thicker and curled with jevtana, I felt generally better with Jevtana than docetaxol, I did not need nuelasta with docetaxol but I did with jevtana, Jevtana can be harder on the blood numbers, but the side effects were generally less. I was not a good example of the efficacy as it was used during strong progression after 12 years of being Gleason 10 stage 4. I stopped it in August after discovering bone marrow being compromised by my bone tumors. I wish you the best

Dan, still no real pain, enjoying every day

[Fairwind in reply to Dan59]

Hi Dan, thanks for the reply....What effect did the Jevtana have on your PSA ? Are you on any active treatment now ? I'm a G-9, 8 years out, running out of options, PSA 325.......

[Dan59 in reply to Fairwind]

The Jevtana basically held psa stable at around 150 till last one. I have been off treatment except a little zytiga for 4 months now.

[Hidden in reply to Dan59]

Dan, great to see that you are still OK. Did the chemo resensitize you to Zytiga?

[Dan59 in reply to Hidden]

I plan to restart zytiga , I stopped it fearing it was keeping my platelets and reds low. Besides I ignore psa at this point and just go by how I feel, And I am pain free. I am thankful for that, but bury my head in sand on looking at alk phos and psa. Haha

[Hidden in reply to Dan59]

I can't see the point in looking at the numbers. Just gets you aggravated for nothing. I would do the same thing.

[Nicnatno in reply to Dan59]

Hey Dan, since you're pain free, this means more fishing for you. Enjoy.

Nick

[j-o-h-n in reply to Dan59]

In the sand? So that was you next to me....Sorry I couldn't say hello... sand in my mouth, and if you said hello I couldn't hear you... sand in my ears.

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 11/09/2018 5:45 PM EST

[leswell in reply to Fairwind]

And thanks for the Post, Fairwind. Also considering Jevtana (after Xtandi) as it was suggested by my husband’s oncologist. G9, 2 ½ years out, Xtandi, Eligard, Xgeva, PSA 320. Still going in monthly for PSAs but also paying less attention to the numbers. Leswell is still feeling well. He sleeps!

[CG67 in reply to Dan59]

My husband (a Gleason 9 with recurrent PC) had run through all the standard treatments. Each worked for about a month and then the PSA started doubling. He started Jevtana with a PSA of about 8 over a year ago. His PSA quickly went down to .2. He has now had 15 (!) treatments. He does have physical side effects, primarily neuropathy, unsteadiness and weakness in legs, though he refuses to use a cane or a walker. His PSA has now slowly come back up to 1.8. At this point, the doctor makes a last minute decision each four weeks (used to be three weeks) about whether it's worthwhile/safe to proceed with the treatment. And his side effects are much more tolerable than Taxotere's.

We don't know what the future will bring, but it's very clear that the Jevtana has prolonged his life and kept the quality good enough that he can enjoy spending time with family and friends. We are very grateful.

[Mathes72]

I started jevtana this past wednesday,had newlasta,an prednisone 10 mg,feel better than on zitiga,slept great,going for my walk an work out at the gym ,still drinking a lot of water,,psa was 24.1 ,6 years out,just doing what my mo tells me.good luck

[Saydeebugz]

My husband has completed his 10 rounds of Jevtana about 30days ago. He did VERY WELL with it, no hair loss, no Neulasta needed, no nausea, BUT chemo brain hit him pretty good, PSA at 0.03... yesterday he started the Radium injections, he is still on Zytiga and prednisone 10mg/day, zytiga has been the worst for side effects (fatigue is the worst). He keeps hydrated, eats lost of raw green veggies (spinach, broccoli, cabbage, etc), does his best to be at the gym several times a week.

[ontheroad589]

This year .

I started with 12 rounds of Docetaxel, and then liver mets showed up on a the CT scan. Lots of them. So the MO started me on Jevtana - now ending round 3.

The side effects for me are wierd, as it is nothing like Docetaxel. I have a few good days after infusion, then a week of holy hell. Constiapation followed by diarrhea, no appetite, extreme fatigue, and bone pain.

By day 13 or 14 things are back to "normal", and then at 21 days we do it again. Overall, it is milder than Docetaxel in my opinion, but the side effects take longer to take effect and the duration is longer.

[GAdrummer]

Each man is different. My husband's dose had to be cut 20% after the first one dropped his ANC from 8,230 to 30 in one week with Neulasta. He has started re-growing hair after 20 cycles of Docetaxel had de-haired him. QOL has been miserable like ontheroad589 except he barely gets back to "normal" a day before the next infusion.

[Izab]

I did cabazitaxel 65 consecutive treatments until couldn't take anymore. PSA climbed to 600 until rapidly dropping to 10 after finishing treatment. Had almost 2 years of remission. Now having 6 treatments cabazitaxel. PSA dropped after 1 treatment by 50. Now stable. PSA 300 at present. Hoping for further drop, seeing onc tomorrow.

Cabazitaxel has a kick but worth it. Had 5 hospitalisations with infection. Now having neulasta which has just been subsidised in Australia which is helping tremendously.

all the beast in your treatment,

Izab

[Izab in reply to Izab]

Now PSA is 252 awesome result. Trusting God. When trouble and uncertainty in life comes, the presence of God is my refuge and place of safety. He is my strong tower.

isab