It might also be of interest that a clinical trial is being funded to investigate whether the tapeworm drug Niclosamide can prevent Covid-19 causing serious illness in high risk kidney patients. Source Kidney Research UK.
Open Access
Published: 18 March 2021
Phase Ib trial of reformulated niclosamide with abiraterone/prednisone in men with castration-resistant prostate cancer
Mama Parikh, Chengfei Liu, Chun-Yi Wu, Christopher P. Evans, Marc Dall’Era, Daniel Robles, Primo N. Lara, Neeraj Agarwal, Allen C. Gao & Chong-Xian Pan
Niclosamide has preclinical activity against a wide range of cancers. In prostate cancer, it inhibits androgen receptor variant 7 and synergizes with abiraterone. The approved niclosamide formulation has poor oral bioavailability. The primary objective of this phase Ib trial was to identify a maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of a novel reformulated orally-bioavailable niclosamide/PDMX1001 in combination with abiraterone and prednisone in men with castration-resistant prostate cancer (CRPC). Eligible patients had progressing CRPC, adequate end-organ function, and no prior treatment with abiraterone or ketoconazole. Patients were treated with escalating doses of niclosamide/PDMX1001 and standard doses of abiraterone and prednisone. Peak and trough niclosamide plasma levels were measured. Common Terminology Criteria for Adverse Events (CTCAE) v4.0 and Prostate Cancer Working Group 2 criteria were used to evaluate toxicities and responses. Nine patients with metastatic CRPC were accrued, with no dose-limiting toxicities observed at all dose levels. The recommended Phase II dose of niclosamide/PDMX1001 was 1200 mg orally (PO) three times daily plus abiraterone 1000 mg PO once daily and prednisone 5 mg PO twice daily. Trough and peak niclosamide concentrations exceeded the therapeutic threshold of > 0.2 µM. The combination was well tolerated with most frequent adverse effects of diarrhea. Five out of eight evaluable patients achieved a PSA response; two achieved undetectable PSA and radiographic response. A novel niclosamide/PDMX1001 reformulation achieved targeted plasma levels when combined with abiraterone and prednisone, and was well tolerated. Further study of niclosamide/PDMX1001 with this combination is warranted.
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Graham49
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Niclosamide is very interesting. Also as a Zinc iontophore. As for this study:
1. That is a wholloping big dose of it.
2. They were abiraterone naive and started on that at the same time. So the clinical response might have been entirely from abiraterone possibly.
3. You can get topical niclosamide very inexpensively now combined with hydrocortisone for eczema. That is what I use 2-3 times per week after bathing. (Much lower dose however.)
Would prefer a Phase In with niclosamide alone. Then a randomized with and without the abiraterone.
Where did you buy it? I see the veterinary formulations. Niclomax is 75% niclosamide. So that would provide access to a sufficient concentration as used in the early trials to overcome AV-7 and enzalutamide resistance. They used 1600 mg three times daily (!) but had no side effects and continued enzalutamide which overcame the resistance. Are you enzalutamide resistant? Claws could be cool.
Not yet, but might try if Xtandi started to fade. You're risking things. I've read it's well tolerated but some say it makes you puke. That might scare u...
My plan is to disconnect my kitchen sink , chop it up to granular size pieces and swallow some each day with a glass of water. This way I can tell my doctor I took every med there is including the kitchen sink..... I betcha he'll be impressed..... The sink needs replacing anyway....
The urologist that implanted tubes into my kidneys told me” We ‘re just plumbers”, also “ this isn’t our fault , so don’t sue us”! we know how important the plumbing is now . I’m pretty sure the uro surgeons makes much more than a union plumber . 😷
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Abiraterone Acetate Plus Prednisone in Newly Diagnosed High-Risk Metastatic Castration-Sensitive Prostate Cancer: Final OS Results
