Given frequent blood tests, etc., you'd think UC Davis would know by now if the 'more bioavailable' niclosamide they're using in this trial is working, right?!! You'd think they'd share their findings asap???
In edit - this makes me wonder, again, if artemisinin (which is used to treat malaria) may have any benefit. Artemisinin works for dogs with bone cancer!! -puts them in remission for years! I know there have been clinical trials using artemisinin for PC - and something came out that was discouraging, but perhaps it can be revisited. This is 10 years old: ncbi.nlm.nih.gov/pmc/articl...
Here's a link to the discussion a few weeks ago about niclosamide, brought up by LearnAll. I copied and pasted Tango's very informative post: about the UC Davis trial
The study a UC Davis uses a niclosamide that is different from the niclosamide used in the trial at the UW Seattle. At Davis they use PDMX1001/niclosamide. This compound made by a Biotech company in Sacramento is absorbed by the gut and makes possible for niclosamide to reach anti cancer levels in the blood. Regular niclosamide is poorly absorbed by the gi tract to reach anti cancer levels without using toxic doses.
clinicaltrials.gov/ct2/resu...
Besides the anti cancer mechanisms you outlined, PDMX1001/niclosamide can resensitize the cancer to abiraterone and enzalutamide They have shown in vitro that niclosamide can revert mechanisms in the cancer cells which make the cancer resistant to abi or enza.
Some info about niclosamide:
ncbi.nlm.nih.gov/pubmed/247...
ascopubs.org/doi/abs/10.120...
health.ucdavis.edu/synthesi...
ncbi.nlm.nih.gov/pubmed/270...
ncbi.nlm.nih.gov/pubmed/285...
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Will their reformulation make a difference? We'll find out in May.
I don't know of any clinical trial data on artemisimin. Why do you think that something that works on bone cancer in dogs will have efficacy on prostate cancer in humans?
A highly respected eastern medicine specialist told us about artemisinin.. He works with humans and their pets. We consulted him a couple years ago after our dog was diagnosed with cancer. He said the artemisinin worked miracles for his mother's breast cancer, and that it works well with other cancers, including prostate cancer, and especially bone cancer. At the time, weren't ready to consider eastern medicine for ourselves - we were very skeptical.
I believe Niclosamide has great potential as a medicine which can prolong zytiga
's loss of response and re-enrgize the therapeutic effect. In a year or two, we will know the bioavailability issue resolved with some complex fancy method..but the price of this new med will be exorbitant...thats how it works for big pharma.
Bio-available niclosamide. Ok all I need is an ultra-sonic liposomal compound system from? I’ve got a dog to experiment with. Just saying . My PSMA-11 68Ga nuclear pharmacology scientist I talked to last August may help. Where from the same home town.
What is the difference between absorption and bioavailability?
Absorption refers to the transfer of a substance from its site of administration into the bloodstream. ... Often these two pharmacokinetic terms (absorption and bioavailability) are considered synonymously, but there is actually a subtle difference between them
They have been saying Turmeric (curcumin) is not bioavailable . So the profiteers wanted some complicated formulation that can be patented and charge you $10000 a month.
Ayurvedic doctors for centuries were giving Turmeric powder along with Black pepper powder and that makes turmeric bio available. But turmeric and black pepper can not be patented and therefore can't generate billions in profits.
So now, they are spreading lie about turmeric that it only "masks" PSA. Baseless rumors.
I had an excellent response to Artesunate, a form of Artemisinin which is more bioavailable. I took it because a genetic test of my prostate cancer had shown amplification of CCND1 (Cyclin D). This is associated with elevated CDK4 and CDK6. It was found that Artemisinin down-regulates CDK4 inducing aptopsis ("Artemisinin Blocks Prostate Cancer Growth and Cell Cycle Progression by Disrupting Sp1 Interactions with the Cyclin-dependent Kinase-4 (CDK4) Promoter and Inhibiting CDK4 Gene Expression* by Jamin A. Willoughby, et al).
Since I took it several years ago, drugs such as Ibrance are available which do the same thing,. Still, it brought my PSA down to near-zero levels and was available from reliable overseas suppliers.
The only side effect I suffered was neutropenia which corrected itself by avoiding use of the drug for several days.
I eventually became resistant to the Artesunate but was able to extend its usefulness for 18 months by using it only when my PSA was on the rise.
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