An good article discussing recent results of using AR targeting drugs like apalutamide with ADT before surgery, continuing for a year after. "Not in all men, but in about 20% the tumor was dead or necrotic." This was before surgery. Worth a read.
vitaljake.com/high-risk-loc...
When I met with the head of Urology at the Cleveland Clinic in 2018, he was very excited about the results from similar(perhaps the same) trials and I was evaluated for participation. Unfortunately, I had the wrong genetic makeup for their trial. Later, I asked a Medical Oncologist at Sloan Kettering in NYC why they didn't prescribe Lupron before surgery as they so often do prior to radiation. He said they had tried that years earlier and even if the tumor shrank, there was no benefit in long term survival.
These new studies seem to have really positive implications.
Locally Advanced Prostate Cancer, at diagnosis
sarms and locally advanced prostate cancer. 
Newly diagnosed for high grade Prostate Cancer
The efficacy and safety of radical prostatectomy and radiotherapy in high-risk prostate cancer: a systematic review and meta-analysis
SBRT for low/intermediate risk prostate cancer has excellent 5-year outcomes
