An mRNA vaccine delivered in hydrogel shows promise as a durable cancer immunotherapy

[fmenninger]

fiercebiotech.com/research/...

[GoBucks]

More good news for mice with melanoma.

[rscic]

A list of clinical trials using mRNA to treat cancer is available at:

cancer.gov/about-cancer/tre... Taken From Dr. Mirkin's weekly newsletter

[TheTopBanana in reply to rscic]

Is that newsletter worth reading?

[rscic in reply to TheTopBanana]

Dr. Mirkin's newsletter has lots of general info & is free .... this wk he just happened to talk about mRNA so he included some items on cancer research.

[dentaltwin]

What's interesting to me here is that in the mRNA vaccines for SARS-COV-2, the primary mechanism is stimulating humoral immunity. Cellular immunity may be engaged too, but AFAIK this has not been determined. Here, the primary goal seems to be to engage cellular immunity.

The other issue is that the tumors here have been engineered to express surface ovalbumin; I'm not sure how this would work with tumors not so immunologically...convenient.