Gat Goren procedure for prostate cancer

[Paver1]

any one hear of recent news about gat goren procedure successfully treating actual cancer? I have varicocele and am wondering if it could have caused my pc

[pjoshea13]

I'm familiar with the work of Gat & Goren and their theory that varicocele causes dangerous levels of free testosterone to go directly to the prostate. I know of one man (from another PCa group) who had his varicocele treated about 6 years ago, but I'm not in touch with him.

The Gat Goren Clinic is in Israel:

pirion.co.il/index.php?opti...

Their latest paper:

pubmed.ncbi.nlm.nih.gov/328...

Paying the price for standing tall: Fluid mechanics of prostate pathology

Yigal Gat 1 2 , Sharon Joshua 1 , Stanimir Vuk-Pavlović 3 , Menachem Goren 1

Affiliations collapse

Affiliations

1 Andrology and Interventional Radiology Unit, Mayanei Hayeshua Medical Center, Bnei Brak, Israel.

2 Department of Condensed Matter Physics, The Weizmann Institute of Science, Rehovot, Israel.

3 Mayo Clinic College of Medicine and Science, Rochester, Minnesota.

PMID: 32833288 PMCID: PMC7754396 DOI: 10.1002/pros.24051

Free PMC article

Abstract

Background: Age-dependent increase in the incidence of benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are both related to cell proliferation and survival controlled by intraprostatic free testosterone (FT) concentration. Paradoxically, BPH and PCa occur as circulating testosterone levels decrease, so any possible relationship between testosterone levels and development of BPH and PCa remains obscure.

Results: In BPH the enlarging prostate is exposed to high testosterone levels arriving directly from the testes at concentrations about hundredfold higher than systemic FT. This occurs because venous blood from the testes is diverted into the prostate due to the elevated hydrostatic pressure of blood in the internal spermatic veins (ISVs). Elevated pressure is caused by the destruction of one-way valves (clinically detected as varicocele), a unique phenomenon related to human erect posture. While standing, human males are ISVs vertically oriented, resulting in high intraluminal hydrostatic pressures-a phenomenon not found in quadrupeds. In this communication, we demonstrate the fluid mechanics' phenomena at the basis of varicocele leading to prostate pathology.

Conclusions: So far, varicocele has been studied mostly for its etiologic role in male infertility and, thus, for its effects on the testes. It is becoming clear that varicocele is a major etiologic factor in BPH and likely also in PCa. Restoring normal testicular venous pressure by treatment of the abnormal ISV's in varicocele has been shown to avert the flow from the prostate with the effect of reducing prostate volume, alleviating symptoms of BPH, and increasing concentrations of circulating FT.

Keywords: benign prostate hyperplasia; human erect posture; testicular venous pressure; varicocele; varicocele occlusion.

© 2020 The Authors. The Prostate Published by Wiley Periodicals LLC.

-Patrick

[Paver1 in reply to pjoshea13]

Thanks for your response and information.

[Graham49 in reply to pjoshea13]

PatrickSince vasectomy is associated with PCa, do you know whether vasectomy also causes a higher level of testosterone to reach the prostate gland?

Graham

[pjoshea13 in reply to Graham49]

Graham,

I doubt it.

-Patrick

[Tall_Allen]

Since testosterone doesn't cause prostate cancer, I seriously doubt it. It is only natural to seek something to blame.