Recent study on Flubendazole for castration resistant PCa - Another repurposed drug

[Graham49]

After reading donits recent post about ferroptosis I did a search on google Scholar and came up with this, and thought it deserved a separate post. I know that some members already use anti malarial drugs for PCa.

Flubendazole, FDA-approved anthelmintic, elicits valid antitumor effects by targeting P53 and promoting ferroptosis in castration-resistant prostate cancer.

Author links open overlay panelXuminZhouaeLibinZouaWenbinChenaTaoweiYangaJunqiLuoaKaihuiWuaFangpengShubXiaoTancYuYangdShengrenCenaChuanyinLiaXiangmingMaoa

doi.org/10.1016/j.phrs.2020... rights and content

Highlights

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Flubendazole, a FDA-approved anthelmintic, may be effective in treating Castration-resistant Prostate Cancer.

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Flubendazole inhibits the cell viability in vitro and tumor growth of Castration-resistant Prostate Cancer in vivo.

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Flubendazole exhibits a synergistic effect with 5-fluorouracil (5-Fu) in chemotherapy of CRPC in vitro and in vivo.

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Flubendazole promotes the Ferroptosis by targeting P53 protein in Castration-resistant Prostate Cancer cells.

Abstract

On account of incurable castration-resistant prostate cancer (CRPC) inevitably developing after treating with androgen deprivation therapy, it is an urgent need to find new therapeutic strategies. Flubendazole is a well-known anti-malarial drug that is recently reported to be a potential anti-tumor agent in various types of human cancer cells. However, whether flubendazole could inhibit the castration-resistant prostate cancer has not been well charified. Thus, the aim of the present study was to characterize the precise mechanism of action of flubendazole on the CRPC. In this study, we investigated the potential effect of flubendazole on cell proliferation, cell cycle and cell death in CRPC cells (PC3 and DU145). We found that flubendazole inhibited cell proliferation, caused cell cycle arrest in G2/M phase and promoted cell death in vitro, and suppressed growth of CRPC tumor in xenograft models. In addition, we reported that flubendazole induced the expression of P53, which partly accounted for the G2/M phase arrest and led to inhibition of the transcription of SLC7A11, and then downregulated the GPX4, which is a major ferroptosis-related gene. Furthermore, flubendazole exhibited synergistic effect with 5-fluorouracil (5-Fu) in chemotherapy of CRPC. This study provides biological evidence that flubendazole is a novel P53 inducer which exerts anti-proliferation and pro-apoptosis effects in CRPC through hindering the cell cycle and activating the ferroptosis, and indicates that a novel utilization of flubendazole in neoadjuvant chemotherapy of CRPC.

[LearnAll]

Flubendazole and Fenbendazole are similar drugs...both are anti helminthic drugs.Fenbendazole is approved for animals and not approved for humans in USA.

They both act by de-stabilizing Microtubules of the cytoskeleton. .thereby disrupting cell structure. .leading to apoptosis (cell death)

What seems strange to me is that this above article is calling an anti-helminthic drug ...an antimalarial drug...sounds like an error.

[donits in reply to LearnAll]

Hello colleagues, I would like to ask what do you think of vaccination again coronavirus and the impact of these vaccinations on cancer cells. At one of the European forums, I heard the opinion that it is worth getting vaccinated and at the same time (= before and sometime after) check how it will affect the PSA level.

[LearnAll]

On Jan01,2020, I took Live Cholera Vaccine (Vaxchora) . My lymphocyte count went up from 2150 to 4245. It came back to 2100 after two months. I am considering a booster dose in mid2021

Please note : Flubendazole Is Not anti malaria drug. It is anti helminthic drug just like fenbendazole.

[LearnAll]

There are whispers that anti tuberculosis vaccine ,BCG also does the same thing Cholera vaccine does. Does anybody has more info about use of BCG

vaccine.ncbi.nlm.nih.gov/pmc/articl...

Swedish study about cholera vaccine and death from PCa

[dhccpa]

I'm sure this will be a controversial post. Prepare to duck.

[dhccpa]

How does flubendazole differ from fenbendazole and mebendazole?

[j-o-h-n]

XuminZhouaeLibinZouaWenbinChenaTaoweiYangaJunqiLuoaKaihuiWuaFangpengShubXiaoTancYuYangdShengrenCenaChuanyinLiaXiangmingMaoa

Aren't these the same lab techs who worked in the Wuhan Institute of Virology in WUHAN, China?

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 12/05/2020 10:52 PM EST

[SeosamhM in reply to j-o-h-n]

HA! ..... And just WHO left the blasted lab door open...???