CareOncology Protocol

[Zolababs]

We have added the CareOncology protocol of mebendazole, metformin, doxycycline, and atorvastatin to my husband’s regimen. We probably started too late, but are hopeful. Has anyone here had success with adding this protocol?

[Kentucky1]

From my point of view judging the success of the COC protocol will be hard to do until we start seeing extended survival rates that exceed the SOC treatments. If SOC is giving us overall survival rates in the 3-7 or so years range on average ,then until we begin to see COC participants exceed the norm,it will be difficult to say it's a success or not. I've been on the protocol for about a little over a year. I can't say it has or hasn't had a positive or negative effect on my cancer. This protocol is intended to limit the alternate metabolic pathways that develop as the cancer becomes less reliant on testosterone and hopefully reduce the damage done by the metastasis. The only published effectiveness so far has been with glioblastoma type brain cancer. If I remember correctly it was purported to extend overall survival by almost 75-100%. Keep in mind most glioblastoma patients live only about a year or so at best. I am hopeful that they are on to something and that this protocol helps me to live a longer life. I view this as just another arrow in the quiver that will help me in my journey with prostate cancer. Time will tell if it's going to prove itself as an accepted standard of care or just another failed hypothesis.

[dhccpa in reply to Kentucky1]

True. And the clocks are ticking as we post.

[Kentucky1]

The COC protocol is a daily regimen. Starting with Atorvastatin 80mg daily, MetforminER 500mg twice a day, Doxycycline 100mg daily alternating monthly with Mebendazole 112mg daily.These doses can change based on patient response ( tolerability). My COC oncologist has just added Metformin 250mg to the Metformin ER and also have gone to daily Mebendazole instead of the every other month rotation. As to why they chose Atorvastatin over Simvastatin is unknown to me. It is my understanding that the lipophilic statins are favored over the hydrophilic.I am also taking Loratadine 10mg daily and Melatonin 60mg after dinner and at bedtime.

[Brianbcollins in reply to Kentucky1]

Dear kentucky1,

I read an article recently mentioning that metformin ER was cancer-causing. has anybody else read this, or am I just having a senior moment?

[Kentucky1 in reply to Brianbcollins]

Unsure of any direct link between Metformin and cancer. There was a report of certain batches of metformin being recalled due to contaminants found as a result of poor manufacturing standards. This contaminant had been linked to cancer. I don't recall the exact contaminant, but it seems to pop up on a regular basis from generic medications manufactured in India with the raw materials being sourced from China.

[Brianbcollins in reply to Kentucky1]

Thank you so much.

[Bigm789 in reply to Kentucky1]

Simvastin is lipohillic

[Zolababs]

👍

[16starsky]

My Husband has been on the COC protocol for about four months now, again not sure yet if its helping at all, but we will try it for a year to see what happens.

[Zolababs in reply to 16starsky]

I pray our husbands get positive results!

[16starsky in reply to Zolababs]

Me too !

[LearnAll]

ncbi.nlm.nih.gov/pmc/articl...

pubmed.ncbi.nlm.nih.gov/299...

jstage.jst.go.jp/article/bp...

[Ramp7 in reply to LearnAll]

I'm not under COC care. I've read Jane McLelland's book. Actually met here earlier this year. Regarding mebendazole, metformin (berberine), doxycycline, and atorvastatin. I take these in a pulse fashion in conjunction with standard SOC regime. Unable to report on any effect, time will tell.

[dhccpa]

I checked into COC but my current insurance premiums are killing me. I decided to wait until I go on Medicare June 1 and will re-evaluate it then. In the meantime, I take fenbendazole, red yeast rice, a Cox 2 inhibitor, and famotidine.

There ia a Care Oncology Group on Facebook that is pretty active.

[Blackpatch]

I have been on COC for 29 months and am getting heartily sick of the taste of those bloody worm tablets... I really dread it when the monthly swap over comes around! I did it in conjunction with eSRT and 9 months of zytiga plus a year of goserelin. Now a year since ADT wore off and my T is at 80% of initial value and PSA remains undetectable, 20 months post-eSRT.

So is that due to the COC, the aggressive ADT or my high PORTOS score, which meant radiation was always going to work? I don’t know, but i’m Not ready to give up the COC yet.

Stuart

[MateoBeach in reply to Blackpatch]

Fennendazole can substitute for mebendazole. It is cheaper bought on Amazon in powder form as dog dewormer and is completely tasteless ( unless you find the idea distasteful). 2 grams or 4 gram envelope of Panacur C, stirred into yogurt is just fine.

[Zolababs in reply to Blackpatch]

We are continuing COC as well.

[MateoBeach]

Most Of these target reducing inflammation as a driver of cancer progression rather than a direct cancer treatment. Good idea IMO but cannot expect immediate response clinically. Not sure why they do not include celecoxib in the mix. I do not take doxycycline as I worry about possible effects on the gut microbiome.

[dhccpa]

I used Aleve and alternated irregularly with aspirin

[dhccpa]

I am out if Aleve now so taking a break. When I restock, I may rotate to ibuprofen for the next round. I haven't yet used any off label Rxes, but I am using fenben, and just began using Ivermectin cautiously.

[goldenfoot]

I did my own experiment with fenbendazole. I am Gleason 7. Since I have had no SOC treatments, i figured that I might be able to tell if fenben was making a difference. So I used the advised amount 5-7 days a week for 3 months. Psa was 13 when I started. It went down to 5. I thought wow! Previous to the 13 reading though it was 7. I continued protocal for 3 months, Psa was 6. Then another 3 months, Psa was 7. Then discontinued for 3 months, Psa was 6.5. Discontinued for another 3 months Psa was 7.5. It is currently 6.5. I don't think that it works for Prostate cancer.

[Bigm789 in reply to goldenfoot]

What are you doing for treatment now protocol,. How much FBZor MBZ did you do ? Take it with 3 oz of EVOO or a fat for absorbtion. ? How many Mg daily ? 3 - 7 days a week for what time frame,. How many lesions in your biopsies, what % of G7 was the +cores,. . Did you do also Statin , Berberine , Depression , quercitin ,curcumin etc? Whats your MRI say what is your PSA. Where did u buy FBZ?Best Bigmls.

[dhccpa]

I can't get any docs around here to write anything. But yes, I'm being cautious and conservative.

[Brianbcollins]

Dear NalMy understanding is that if you are over 64 , they will not give you the cholera vaccine...please tell me how you did it

[dhccpa]

I'll check into that. I'll be on Medicare soon and have greater flexibility.

[HerbieP]

I've been on COC protocol only two months. I understand it's a protocol we'll stay on until we get to go meet our maker. I understand it's no cure, but it slows down the progression, more time is more goodness.

[Zolababs in reply to HerbieP]

That’s how we look at it as well.

[Brianbcollins]

Thanks for this info, and for all your help thru the years.