BRCA variant mutation and Joe Tippens protocol using Fenbendazole.

[sgrama]

What does it mean if you had a BRCA done and it says there is a variant mutation? Also is anyone here doing the Joe Tippens protocol and if so did you have any good results from it?

Thanks

[Tall_Allen]

It means that your BRCA gene has an error in it that may impair it's function. BRCA'S job is to repair DNA damage. If it has errors in certain places, DNA damage can accumulate and cause cancers. Not all errors impair function.

[Grumpyswife]

Use the search and find some members who are using the Tippens protocol.

My husband started taking Fenbendazole on 9/4/19 after starting Xytiga 8/12/19. I felt it was a good time since he is having bloodwork every two weeks anyway.

Coincidentally, his PSA remained stable last time and we were pleasantly surprised. Success with Zytiga after Xtandi failure is only 15-30% likely.

[cigafred]

As per mjbach, I have posted my positive fenbendazole experience, though still early days.

[abmicro]

I did complete and thorough genetic testing at Stanford and they found absolutely no gene mutations that would explain why I got high grade prostate cancer at Age 48. Gene mutations only explain about 10% of all cancer cases per Stanford Genetics. The remaining 90% of cases can be mostly be blamed on environmental factors such as 1st or 2nd hand smoke, carcinogens in food, plastics, water, air, chemicals, etc, poor diet, stress, and other factors.

If you found a gene mutation, you can use that information to your advantage to hit cancer with a treatment that has tested to work better on that mutation.

[2dee]

If I understand correctly there are BRCA1 and BRCA2 genes which may become mutated in a family bloodline. If mutated in a family member they can then be passed down. My grandfather died of PCa and my mother died from breast cancer age 53. One of her sisters and 7 of her sister's children died young of various cancer.

I tested positive for BRCA2 mutation likely passed down from good old gramps through mom. It meant I had a 70% chance of developing certain cancers including Melinomas, breast, and PCa. I had a Melinoma removed in 1984 and Dx with stage 4 PCa in 2018. I reached out to all gramps bloodline with my results and encouraged them to be genetically tested and use the knowledge to better judge their own cancer testing and treatment options. My daughter was spared the mutation. BRCA and other mutations can occur for many reasons with familial being one.

I learned too late to affect my early cancer screening decisions. My PSA had been inching up for years but no doc worried about it until it jumped from 7.5 to 1300+ I think due to inflammation caused by a severe bout with the flu end of 2017.

Had I known earlier I might have been able to effect a cure rather than counting days.

Once Lupron stops working I am now eligible for PARP inhibitors treatment options.

If you have family history seek a genetic counselor to recommend genetic testing. If positive then be more aggressive with treatments.

2Dee

[kapakahi]

my PSA dropped for 2 successive tests - by about 1/3 in total - after I started taking fenben, but the 3rd test showed a rise of about 1/3. So I don't know what's going on - is it working but I had some kind of inflammation? Or is it not working?

I continued to take it for another two weeks, then asked my urologist to order another PSA - I have PCa, after all, and my PSA has been known to rise dramatically in two weeks, so I thought it might be a good idea to test again to see if the rise was an anomaly or if it had risen even more, and if it had risen then I'd have to decide what to do about it.

My doctor refused to order the test, telling me I should get tested only every 3 months. This is the guy who told me 3 months ago that PCa had recurred, referred me for Axumin and MRI scans - both of which found suggestions of PCa - and then told me I could consider radiation. Now he refuses another PSA and says only every 3 months. And he also said I could ask my primary care doctor to order a test. Well, if the PCP orders it, why not the guy who is supposedly treating me for PCa?

I don't know what his trip is, but I'm finding another urologist. I need to find out what my PSA is.

[LeeLiam in reply to kapakahi]

My understanding is you don't need a doctor to get a PSA test. I get mine from Life Extension for $31. lifeextension.com/vitamins-...

[Shanti1 in reply to kapakahi]

Hi Kapakahi- Since you are looking for another doc, instead of looking for a urologist, consider switching to a medical oncologist (even better if you can find one that specializes in prostate cancer). Many men on this site report that Urologists are not educated enough in prostate cancer to competently treat, I know this was my husband's experience as well.

[kapakahi in reply to Shanti1]

my first urologist was highly competent - this new one I don't know - he does do biopsies, and he ordered the scans and advised radiation, though he doesn't do radiation himself - it's hard to tell how competent he is, but I already hate his attitude -

[j-o-h-n in reply to kapakahi]

Say ciao to your a-hole doctor..... post here where you live so maybe someone can recommend a good MO for you....

Good Luck, Good Health and Good Humor

j-o-h-n Tuesday 10/08/2019 12:24 AM DST

[StayingOptimistic in reply to kapakahi]

Did you find out what the psa is? I am about to start fenbendazole and am just worried about side effects/ liver damage, etc.

thanks

[AlanLawrenson]

Get another doctor who is attentive to your concerns. I went to three urologists, and a radiation oncologist, before I started proton beam therapy in Seoul, South Korea.