Who all here are on the care oncology protocol and taking mebendazole and doxycycline in addition to metformin and statin ?
How is it working for you ?
Dad,83, takes statin and metformin - I was wondering if I should add mebendazole and doxycycline. Any common major side effects ?
ivermectin is also easily available in India.
He is currently doing well on orgovyx and Xtandi.
I'm on the protocol. I have zero idea if it makes any difference as I'm also on Lupron injections and Xtandi. I get no side effects from Mebendazole. From Doxycline, I get photosensitivity in my skin, particularly backs of hands and top of head when the sun shines. As I'm in the UK I tolerate it well in the winter weather but in the summer have to keep covered up more, hat, long sleeves etc. Not tried ivermectin yet
Hi, what is your Doxy dosage do take it without breaks ?
I take 100 mg capsules daily for Doxycline for 4 weeks and then come off and do 4 weeks on Mebendazole. Sometimes in summer time I only do 1 or 2 weeks of Doxycline.
Right now on Dr. Makis protocol - for me it's 120mg IVM along with 600mg Mebendazole twice daily. I cycle the doxy few weeks on off. next scan in afew months. So far feel ok.
120 mg ivermectin. Thats a lot isn’t it. Here in India we get ivermectin tablets of 12 mg each. Did you start that dose all at once or titrated it up ?
No , Started with 12mg every few days increased by 12mg till I reached 108mg after 3wk increased to 120mg. Dr Makis calls for 1mg/kg . some are doing 150mg. watch his interviews on Rumble.
Ivermectin has low toxicity and you can go even up to 2/2.5 mg/kg in hard cases. I used to take 144 mg a day for my 75 kg.
The problem with Ivermectin is his poor absorption and solubility.
It can be dissolve in alcohol or dmso.
So I have stopped just taking the tablets with water and started to make a tincture with hot vodka and grapefruit juice.
U can visit curt Michael Graydon page and read every thing about it,he made some simple videos to explain the process.
By the way I'm doing high does Artemisinin protocol and fenbendazole too.
Since I have started the Artemisinin protocol 5 weeks ago my lymph nudes on my neck have shrinked by 50% to my touch.
I have changed my diet to strict carnivore diet
You can find a lot of information in his page.
Good luck
Question is Why do we all develop diabetes and cholesterol issues when taking these other meds and med plans. That is med induced diabetes, we're you told this could happen when you started down this multi medication treatment plan??? I was told I could wait for my surgery and when I did have my radical the cancer cells had escaped the prostate capsule and they closed me and put me on ADT, which has been great but I was Ajay Todd I had a misdiagnosis as well. No one wants to hear that after but lo n behold here we are still kickin and won't stop either.
What is the effect of Ivermectin on Prostate Cancer?
ChatGPT said:
Ivermectin, traditionally an antiparasitic medication, has demonstrated potential anticancer properties in preclinical studies, particularly concerning prostate cancer. Laboratory research indicates that ivermectin can inhibit the growth of prostate cancer cells through multiple mechanisms:
Inhibition of Androgen Receptor (AR) Signaling: Ivermectin has been shown to reduce AR and prostate-specific antigen (PSA) protein levels in both androgen-sensitive and enzalutamide-resistant prostate cancer cell lines. This suggests that ivermectin may enhance the effectiveness of existing AR pathway inhibitors, potentially offering a strategy against castration-resistant prostate cancer.
PMC
Induction of Cell Cycle Arrest and Apoptosis: Studies have found that ivermectin can arrest the cell cycle at the G0/G1 phase and induce apoptosis in prostate cancer cells. This effect is associated with increased DNA damage and the activation of apoptosis markers, indicating a direct cytotoxic effect on cancer cells.
ResearchGate
+1
Nature
+1
Nature
Targeting of Specific Proteins: Ivermectin interacts with proteins such as FOXA1 and Ku70/Ku80, leading to the blockade of AR signaling transcription and deficiency in DNA double-strand break repair mechanisms. This interaction contributes to the suppression of prostate cancer cell viability.
PMC
+2
Nature
+2
ResearchGate
+2
Additionally, eprinomectin, a derivative of ivermectin, has been studied for its anticancer effects. Research indicates that eprinomectin can suppress the growth and metastatic behavior of prostate cancer cells by targeting the β-catenin signaling pathway.
PubMed
Important Considerations:
While these findings are promising, it's crucial to note that the current evidence is primarily based on laboratory and animal studies. There is a lack of clinical trials evaluating the safety and efficacy of ivermectin or its derivatives in human patients with prostate cancer. Therefore, ivermectin is not approved for prostate cancer treatment, and its use for this purpose should not be pursued outside of clinical research settings.
For those interested in exploring emerging treatments or participating in clinical trials, consulting with an oncologist or a specialist in prostate cancer is recommended. They can provide guidance on the latest research developments and potential opportunities for involvement in clinical studies.
Good Luck, Good Health and Good Humor.
j-o-h-n
All I can say is I got my husband on The Care Oncology Protocol along with other off label drugs and He is doing very well. He had orginally Low volume metastatic (12 possibly-retroperitoneal)lymph node disease. G9, 3 mutations that make it very aggressive. But It's not behaving aggressively according to MO. He now has been restaged Oligometastic and had 1 additional lymph node show up in 19 months. No ADT. Nubeqa only. He had radiation to prostate only. All cancer in prostate is gone. He has 3 lymph nodes in common right and left illiac and external illiac that he plans on getting SBRT to them. No more urinary issues. So I say a WIN so far. So he will continue with the protocol. He has had GI issues lately with all the supplements. So go easy on introducing new supplements, RX, etc.
Two years since surgery.
Effects of Metformin and Statins on MCRPC
Is One Statin Better than Another. 
Synergy of Metformin and Statins for improved OS in APC
